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| 乳癌患者外周血及肿瘤局部单个核细胞亚群分析 | |
| 引用本文： | 孙孟红,郑国豪. 乳癌患者外周血及肿瘤局部单个核细胞亚群分析[J]. 临床与实验病理学杂志, 1988, 0(4) |
| 作者姓名： | 孙孟红 郑国豪 |
| 作者单位： | 安徽医科大学病理解剖教研室(孙孟红)，安徽医科大学病理解剖教研室(郑国豪) |
| 基金项目： | 中国科学院自然科学研究基金 |
| 摘 要： | 对13例女性乳癌患者外周血MNC(半个核细胞)与15名正常女性比较时发现,乳癌患者血中Leul~+细胞及DR~+细胞较低(P<0.05,P<0.01),Leu2a~+细胞较高(P<0.01),Leu3a/Leu2a比值下降(P<0.001),从数量上反映患者机体细胞免疫功能紊乱,并发现可能存在的Leu3a~+、Leu2a~+双标记细胞增多的现象,也可能与免疫抑制有关。DR~+细胞的减少由何引起有待于进一步研究。配对资料分析表明:癌周间质MNC亚群与血中MNC各亚群水平相近(Leu7、Leullb细胞除外),而癌间间质则显示较低的MNC水平。 |
| 关 键 词： | 乳癌间质 外周血 单个核细胞 |
Study of the Subsets of Mononuclear Calls in the Peripheral Blood & Local Tumor of Breast Carcinoma Patients |
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| Sun Menghong et al Dept.of Pathology,Anhui Medical University. Study of the Subsets of Mononuclear Calls in the Peripheral Blood & Local Tumor of Breast Carcinoma Patients[J]. Chinese Journal of Clinical and Experimental Pathology, 1988, 0(4) | |
| Authors: | Sun Menghong et al Dept.of Pathology Anhui Medical University |
| Abstract: | The mononuclear cells(MNC)in the peripheral blood of 13 pati-ents with breast carcinoma were compared with 15 normal women,& those in the peripheral blood & stroma of carcinoma of 10 caseswere studied.The results showed that there were a significant red-uction of T cells & HLA-DR cells.increase of T/c subset & redu-ction of T_H/Ts ratio in patients in comparison with normal.Thesechanges presumed the tumors to be disorders of cellular immunity,& the increase of Leu 2a might be with immune suppression.Matcheddata of blood & local lesions of 10 cases showed that the numbers ofsubsets of MNC except Leu 7~+ B_1~+ cells peripheral blood & peritu-mot stroma were closely related but intratumor had less number ofsubsets of MNC. |
| Keywords: | stroma of breast carcinoma peyipheral blood mononuclear cell |
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