艾司西酞普兰与氟西汀门诊治疗抑郁发作的临床研究

目的：探讨艾司西酞普兰门诊治疗抑郁发作的疗效及安全性。方法：将门诊符合CCMD-3抑郁发作诊断标准的患者100例随机分成艾司西肽普兰组及氟西汀组各50例,艾司西酞普兰最大剂量30mg/d,氟西汀最大剂量60mg/d,采用汉密尔顿抑郁量表（HAMD）减分率评定疗效,用TESS评定不良反应,观察时间为6周,结果：艾司西酞普兰组有效率70%,治愈率44%;氟西汀组有效率64%,治愈率36%。两组比较无显著性差异（P〉0.05）。艾司西酞普兰主要不良反应为食欲减退（10%）、恶心（8%）、头晕、（6%）、口干（2%）,与氟西汀比较无显著性差异。结论：艾司西酞普兰门诊治疗抑郁发作的疗效确切、安全,且起效快、副反应小,经济上大多能承受,可以广泛应用。

Clinical study of Escitalopram and Fluoxetine in the treatment of depression in outpatient

Objective： To discuss the efficacy and safety of Escitalopram in the treatment of depression in outpatient. Methods： 100 outpatients who met the Chinese of Medical Disorders（ CCMD -3 ） criteria for depression were randomly divided into Escitalopram group （50 cases）and Fluoxetine group（50 cases） , Escitalopram maximum dose of 30mg/d, and Fluoxetine maximum dose of 60mg/d. HAMD was used to assess efficacy, and TESS was used to assess adverse reactions,observation time of six weeks. Results：The effective rate and cure rate of Escitalopram were 70% and 44% respectively, Fluoxetine were 64% and36% ; the two ~oups were not significantly different （ P 〉 0.05 ）. Anorexia （ 10% ）, nausea （ 8% ）, dry mouth （ 2% ）, dizziness （6%） were the most frequently reported adverse events in escitalopram group and fluoxetine group, there were not significantly different. Conclusion：The curative effect of Escitalopram outpatient treatment of depressive episode is accurate, and safe, fast onset of action, small adverse reaction, can be widely applied.