血必净对椎间盘突出组织中巨噬细胞表达的影响

[目的]研究中药血必净注射液对椎间盘突出组织中巨噬细胞CD68表达的影响。[方法]以猪为实验动物，手术制作椎间盘突出的动物模型，用血必净试验治疗，检测椎间盘突出组织中CD68表达情况。[结果]模型组CD68阳性率为11／16，低剂量组CD68阳性率为7／16，高剂量组CD68阳性率为6／16，2组与模型组比较P〈0．05。[结论]椎间盘突出组织中的巨噬细胞是引起腰腿痛的重要病理生理基础之一，血必净对其有明显的下调作用，为血必净治疗椎间盘突出症提供了一定的基础理论依据。

Effect of injectable xuebijing on macrophage of intervertebral disc hernial tissue

[Objective]To investigate the effect of injectable xuebijing on macrophage ofimervertebral disc hernial tissue.[Method]The pigs were used as animal models after surgery in the intervertebral disc.Macrophage in herniated disc tissue were observed with the immunohistochemical method after it was treated by injectable xuebijing.[Result]Macrophage were found in 11 of 16 herniated disc tissue in the model group,were found in 7 of 16 herniated disc tissue in the low dose xuebijing group,and were found in 6 of 16 herniated disc tissue in the high dose xuebijing group,compared to the model group,all P<0.05.[Conclusion]The macrophage in the herniated disc tissue may be one important factor in the pathogenesis of intervertebral disc herniation,injectable xuebijing could reduce the levels of macrophage in herniated disc tissue in evidence.In theory,injectable xuebijing could be used to treat the intervertebral disc herniation.