慢性阻塞性肺疾病患者急性期白细胞介素-6及C反应蛋白检测的临床意义

目的　探讨白细胞介素 6 (IL 6 )及C反应蛋白 (CRP)在慢性阻塞性肺疾病 (COPD)急性期发病机制中的作用。方法　应用诱导痰方法 ,收集 2 0例急性期COPD患者、16例稳定期COPD患者和 10名健康不吸烟者的痰液。对血清中CRP浓度进行检测 ,并用放射免疫法测定痰液中IL 6水平。结果　急性期COPD组IL 6、CRP水平明显高于稳定期COPD组和正常对照组 (P均 <0 0 5 ) ;急性期COPD组痰液中IL 6水平与血清中CRP水平呈显著正相关 (r=0 4 5 5 ,P <0 0 5 ) ,而与 1s用力呼气容积 (FEV1)呈显著负相关 (r=0 5 13,P<0 0 1) 。结论　IL 6及CRP参与了急性期COPD的气道炎症反应 ,并可将其作为检测COPD患者急性感染存在的一项重要敏感指标

Clinical value of detecting interleukin-6 and C-reactive protein in acute-staged chronic obstructive pulmonary disease

Objective To evaluate the role of interleukin 6 (IL 6) and C reactive protein (CRP) in the pathogenesis of chronic obstructive pulmonary disease (COPD) at its actue stage.Methods Induced sputum samples were obtained from 20 patients with acute COPD,16 patients with stable COPD and 10 healthy nonsmokers.Serum CRP level was tested,and sputum IL 6 level was measured by radioimmunoassay technique.Results IL 6 and CRP levels at acute stage of COPD were significantly higher than those in the stable stage of COPD group and the healthy group (P<0.05).IL 6 level at acute stage of COPD patients correlated positively with the serum level of CRP (r=0.455,P<0.05),however,IL 6 at acute stage of COPD patients was negatively related with forced expiratory flow in one second FEV 1 (r=0.513,P<0.01).Conclusion IL 6 and CRP are involved in airway inflammation at acute stage of COPD,they can be used as an important sensitive indicator in COPD exacerbation.