Abnormal connectivity in the posterior cingulate and hippocampus in early Alzheimer's disease and mild cognitive impairment |
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| Institution: | 1. Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA;2. Department of Biostatistics, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA;3. Center for Imaging Science, Johns Hopkins University, Baltimore, MD 21218, USA;4. Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD 21218, USA;5. Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA;1. Department of Neurology, Affiliated Drum Tower Hospital, Jiangsu Key Laboratory for Molecular Medicine, Nanjing University Medical School, Nanjing, 210008, China;2. Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, 210008, China;3. Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, 210008, China;4. Department of Radiology, Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing, 210008, China |
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| Abstract: | BackgroundBrain imaging studies of early Alzheimer's disease (AD) have shown decreased metabolism predominantly in the posterior cingulate cortex (PCC), medial temporal lobe, and inferior parietal lobe. This study investigated functional connectivity between these regions, as well as connectivity between these regions and the whole brain.MethodsFunctional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) studies were performed in subjects with early AD, mild cognitive impairment (MCI), and normal controls.ResultsThe data indicate both decreased fiber connections and disrupted connectivity between the hippocampus and PCC in early AD. The MCI group showed reduced fiber numbers derived from PCC and hippocampus to the whole brain.ConclusionsThe fMRI and DTI results confirmed decreased connectivity from both the PCC and hippocampus to the whole brain in MCI and AD and reduction in connectivity between these two regions, which plausibly represents an early imaging biomarker for AD. |
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