临产孕妇凝血功能指标及血细胞参数变化的研究

目的探讨临产孕妇凝血功能指标、血细胞参数的变化及其临床意义。方法对425例临产孕妇(临产孕妇组)和139例健康非孕妇女(健康对照组)进行凝血功能指标:凝血酶原时间(PT)、活化部分凝血活酶时间(aPTT)、凝血酶时间(TT)、纤维蛋白原(Fbg)、D-二聚体(D-D);血细胞参数:血红蛋白浓度(HGB)、红细胞比积(HCT)、红细胞计数(RBC)、红细胞体积分布宽度(RDW)、白细胞计数(WBC)、血小板计数(PLT)、血小板体积分布宽度(PDW)检测和分析。结果 (1)临产孕妇的Fbg、D-D、RDW、WBC、PLT、和PDW高于健康对照组(P0.01),两组差异有统计学意义;(2)临产孕妇的PT、HGB、HCT、RBC低于健康对照组(P0.01),两组差异有统计学意义;(3)临产孕妇的aPTT、TT与健康对照组无明显变化(P0.05),两组差异无统计学意义。结论临产孕妇血液处于高凝状态,可出现不同程度的缺铁性贫血。产前进行凝血功能指标及血细胞参数检测,对预防和冶疗产科一些并发症有极其重要的临床意义。

Study on the Change o Blood Coagulation Function Indexes and Blood Cell Parameters in Parturient Pregnant Women

Objective To investigate the change of blood coagulation function indexes and blood cell parameters in parturient pregnant women and its clinical significance.Methods 425 cases of parturient pregnant women（parturient woman group） and 139 cases of non-pregnant women （control group） were detected for blood coagulation function indexes：prothrombin time（PT）,activated partial thromboplastin time（aPTT）,thrombin time（TT）,fibrinogen（Fbg）,D-Dmier（D-D）;blood cell parameters：hemoglobin （HGB）,hematocrit （HCT）,red blood cell count （RBC）,red blood cell distribution width（RDW）,White blood cell count （WBC）,platelet count （PLT）,platelet distribution width （PDW）,to analyzer after detected.Results （1）There were statistical differences of the levels of Fbg,D-D,RDW,WBC,PLT,PDW in parturient women were higher compared with the non-parturient women （ P 0.01）;（2）There were statistical differences of the levels of PT,HGB,HCT,RBC in parturient women were lower compared with the non-parturient women （ P 0.01）;（3）There were no statistical differences of the levels of aPTT,TT in parturient women were no obviously change compared with the non-parturient women （ P 0.05 ）.Conclusions Hypercoagulabale state and different degree of iron deficiency anemia occur in parturient pregnant women.The detection of blood coagulation function indexes and blood cell parameters plays an important role in preventing from complications.