共聚焦激光显微内镜对组织学胃炎的诊断

目的 评价共聚焦激光显微内镜检查对于组织学胃炎的诊断价值.方法 共有149名患者进行共聚焦激光显微内镜检查.对标准部位和局灶性病变进行共聚焦扫描检查,然后对检查部位进行靶向活检.系统评价共聚焦激光显微内镜检查的结果与组织学诊断结果之间的关系.结果 共聚焦激光显微内镜检查对于萎缩诊断的敏感度、特异度、准确度分别为83.6%、99.6%、97.5%.对于中-重度中性粒细胞活动性诊断的敏感度、特异度、准确度分别为81.9%、99.3%、95.8%.对共聚焦图像进行分组观察,观察者间和观察者内一致性的平均Kappa值分别为0.749和0.811.结论 共聚焦激光显微内镜检查对于组织学胃炎的诊断具有很好的真实性和可重复性,对于组织学胃炎的判断具有潜在的临床应用价值.

Confocal laser endomicroscopy in diagnosis of histological gastritis

Objective To assess the diagnostic value of confoeal laser endomicroscopy(CLE) in histological gastritis.Methods A total of 149 patients underwent CLE.Standard locations and focal lesions were examined by confocal imaging, and specimens were taken by targeted biopsy.The relationship between confocal images and histological findings were studied systemically.Results The sensitivity,specificity and accuracy of CLE in diagnosis of atrophy were 83.6%,99.6%and 97.5%,respectively;and those in moderate to severe neutrophil infiltration were 81.9%,99.3%,and 95.8%,respectively.The mean kappa values for inter-and intra-observer agreement on the classification of confocal images in groups were 0.749 and 0.811 respectively.Conclusion The validity and reproducibility of CLE in diagnosis of histologic gastritis are promising,which might warrant its further application in clinical practice.