直肠癌不同治疗方案干预效果比较及对相关因子水平的影响分析

目的 对两种微创手术以及开腹手术在低位直肠癌根治术后保留泌尿生殖功能进行对比分析,同时评价对血清白细胞介素-10水平的影响.方法 本研究选取2D腹腔镜手术治疗患者30例,3D腹腔镜手术治疗者30例以及开腹手术者38例作为对照,分析对三种不同治疗方案术后保留泌尿生殖功能情况以及对血清白细胞介素-10水平的影响,研究中使用SPSS16.0软件分析和统计数据.结果 2D腹腔镜手术组以及3D腹腔镜手术组患者术后3个月随访均未见严重泌尿功能障碍者;开腹手术组检出2例(5.26％)为严重障碍;三组差别未见统计学意义.男性和女性术后生殖功能情况分析提示开腹手术组情况最差,3D腹腔镜手术组最佳,P＜0.05.手术前三组患者的IL-10水平未见显著差别,2D腹腔镜手术组患者IL-10水平为38.85 ±5.43pg/mL,3D腹腔镜手术组为39.04±5.99pg/mL,开腹手术组则为38.35±5.77pg/mL;手术后以开腹手术组水平最高(27.01±2.08pg/mL),3D腹腔镜手术组最低(12.85±2.43pg/mL),P＜0.05.此外,IL-6术后随访水平开腹手术组水平也最高,P ＜0.05.结论 微创手术对于低位直肠癌患者术后恢复泌尿生殖功能以及减低炎症应激反应来说都更显优势,特别是3D腹腔镜微创手术在减低炎症应激反应方面效果显著,值得临床推广.

A Study of Changes of Relative Serum Factors in Different Treatment Regimens of Rectal Cancer Before and After Intervention

Objective To compare the effects of two minimally invasive procedures and laparotomy on the retention of urogenital function after radical resection of low rectal cancer,and to evaluate the effect of serum interleukin-10 on serum levels.Methods In this study:30 patients underwent 2D laparoscopic surgery,30 patients underwent 3D laparoscopic surgery,and 38 patients underwent open surgery.The patients were treated with three different treatment regimens.The effect of the 10-level of the study was analyzed using SPSS 16.0 software and statistical data.Results There were no significant urinary dysfunction in the two-month followup of the patients undergoing 2D and 3D laparoscopic surgery group and there were 2 cases(5.26％)in the laparotomy group.There were no significant differences among groups.Both men and women reproductive function analysis showed that the laparotomy group was the worst,3D laparoscopic surgery group was the best,P ＜0.05.There was no significant difference in IL-10 level among the three groups before operation,and the level of IL-10 was 38.85 ± 5.43pg/mL in 2D laparoscopic surgery group and 39.04 ± 5.99pg/mL in 3D laparoscopic surgery group(27.01 ± 2.08pg/mL),in open surgery,the lowest in the 3D laparoscopic surgery group (12.85 ± 2.43 pg/mL),P ＜ 0.05.The level of IL-6 was the highest in the open surgery group,P ＜ 0.05.Conclusion Minimally invasive surgery has a greater advantage in the recovery of urogenital function and the reduction of inflammatory stress in patients with low rectal cancer.In particular,3Dlaparoscopic minimally invasive surgery is effective in reducing inflammatory response.It is worthy of clinical promotion.