血Lp-PLA2、Hcy、UA水平与血脂正常脑梗死患者的相关性分析

目的 探讨血Lp-PLA2、Hcy、UA水平与血脂正常脑梗死患者的相关性.方法 在2015年10月至2016年10月期间,选取我院神经内科收治的100例血脂正常脑梗死患者作为研究对象.选取同期进行体检的健康人50例作为对照组.比较两组受试者高血压发生率、血清LP-PLA2、Hcy、UA、Hs-CRP水平,Spearson和logistic多元回归分析,不同NIHSS评分与血清LP-PLA2、Hcy、UA水平的关系.结果 脑梗死组患者高血压发生率、血清LP-PLA2、Hcy、UA、Hs-CRP水平均显著高于对照组(P＜0.05).经过Spearson相关性分析,脑梗死组患者血清LP-PLA2与高血压、Hs-CRP无相关性,与Hcy、UA呈正相关关系.经过多元回归分析,血清LP-PLA2、Hcy、UA水平上升是脑梗死发病的独立危险因素.脑梗死患者NIHSS评分越高,血清LP-PLA2、Hcy、UA水平越高(P＜0.05).结论 血清LP-PLA2、Hcy、UA与血脂正常脑梗死有密切关系,对血脂正常脑梗死临床诊断、评估预后有重要意义.

Correlation Analysis of Blood Lp-PLA2, HCY,UA Levels in Cerebral Infarction Patients with Normal Blood Lipid

Objective To investigate correlation analysis of blood Lp-PLA2,HCY,UA levels in cerebral infarction patients with normal blood lipid.Methods From October 2015 to October 2016,100 patients with normal blood cerebral infarction treated in neurology department of our hospital were selected as the subjects.Healthy people were selected from examination in 50 cases as control group.The incidence of hypertension,serum LP-PLA2,Hcy,UA,Hs-CRP levels were measured.Based on the Pearson analysis and multiple regression analysis,the relationship between different NIHSS scores and serum levels of LP-PLA2,Hcy and UA were compared between two groups.Results The incidence of cerebral infarction,serum LP-PLA2,Hcy,UA,Hs-CRP in patients with cerebral infarction were significantly higher than those in control group (P ＜0.05).By Pearson correlation analysis,LP-PLA2 in patients with cerebral infarction had no correlation with hypertension and hs-CRP,had positive correlation with Hcy 、UA.Through multiple regression analysis,serum LP-PLA2,Hcy,UA levels are independent risk factors for cerebral infarction.The higher the NIHSS score was,the higher the serum LP-PLA2,Hcy and UA levels were (P ＜ 0.05).Conclusion Serum levels of LP-PLA2,Hcy and UA are closely related to normal blood cerebral infarction,and have important significance for clinical diagnosis and prognosis evaluation of normal blood cerebral infarction.