血清白蛋白水平对腹膜透析患者残余肾功能的影响

Objective To study the effect of serum albumin(Alb) levels on residual renal function (RRF) in peritoneal dialysis patients. Methods Fiftyfour patients accepting peritoneal dialysis were divided into two groups base- d on the serum levels of Alb,including group A (Alb≥35 g/L) and group B(Alb < 35g/L). The serum levels of Alb, creatinine, urea nitrogen, IL-6, TNFα were determined. 24 - hour urine and peritoneal dialysis fluids were remained and urea nitrogen, creatinine, RRF, and others were determined. The above mentioned marks and RRF were observed in follow- up visit. Results The proportion of diabetic nephropathy patients in group B was higher than in group A. Correlative analysis indicated that a negative correlation was found between the levels of Alb and mediators of inflammation IL - 6 and TNF - α. The de-crease in RRF is time- dependent in all selected patients. But the RRF in group B began to decline since peritoneal dialysis 6th month, there is lower compared with 1st month. After peritoneal dialysis 12th months the RRF in group A also significant declined, but the degree of declining in group B was greater. Correlative analysis indicated that the negative correlation was found between RRF and the levels of Alb, otherwise the positive correhtion was found between the RRF and mediators of inflammation IL - 6 and TNF - α. Conclusions The low levels of Alia resulted from malnutrition was one of the factors to decline RRF in per-itoneal dialysis patients. The high levels of mediators of inflammation accelerated the deterioration of the RRF.

The effect of serum albumin levels on residual renal function in peritoneal dialysis patients XIA