| IDO的免疫调节机制及在移植耐受和肿瘤逃逸中的作用 |
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| 引用本文： | 翁明哲,徐军明. IDO的免疫调节机制及在移植耐受和肿瘤逃逸中的作用[J]. 国际外科学杂志, 2009, 36(7): 703-706. DOI: 10.3760/cma.j.issn.1673-4203.2009.10.020 |
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| 作者姓名： | 翁明哲 徐军明 |
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| 作者单位： | 上海市第一人民医院肝移植科,上海,200080; |
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| 摘 要： | 吲哚胺2,3双加氧酶(IDO)是一种能分解色氨酸的细胞内血红素单体蛋白,实验证明通过色氨酸的剥夺和分解产物聚集可以抑制T细胞成熟并促其凋亡.随着对IDO免疫调节机制研究的不断累积,其在器官移植和肿瘤治疗等领域的临床应用前景令人期待.本文就IDO的免疫调节机制及在移植耐受和肿瘤逃逸中的作用做一综述.
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| 关 键 词： | 吲哚胺2,3双加氧酶 移植耐受 肿瘤逃逸 |
Immune regulative mechanism of indoleamine 2,3-dioxygenase and its effects in transplantation tolerance and tumor escape |
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| Abstract: | Indoleamine 2,3-dioxygenase(IDO)is an intracellular hemeprotein enzyme which catalyses the essential amino acid tryptophan.Accumulating evidences have demonstrated that tryptophan depletion and its toxic metabolites can suppress local allogeneic T cell proliferation and lead to apoptosis.With the study of the mechanism of immune regulation of IDO goes further,it have emerged as a proming enzyme in organ transplantation and tumor treatment.We reviewed in the article the immune regulative mechanism of IDO and its effects in transplantation tolerance and tumor escape. |
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| Keywords: | indoleamine 2 3-dioxygenasetransplantation tolerancetumor escape |
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