| 痰湿证大鼠模型肝脏脂质合成基因的表达 |
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| 引用本文： | 刘涛,赵岩,李学军,刘长勤,杨叔禹. 痰湿证大鼠模型肝脏脂质合成基因的表达[J]. 国际中医中药杂志, 2009, 31(4): 391-392. DOI: 10.3760/cma.j.issn.1673-4246.2009.05.002 |
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| 作者姓名： | 刘涛 赵岩 李学军 刘长勤 杨叔禹 |
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| 作者单位： | 海南医学院方剂教研室,海口,571101;福建医科大学附属厦门市第一医院糖尿病研究所,厦门,361003; |
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| 基金项目： | 福建省卫生厅创新课题(项目编号:2007-CXB-10):厦门市科技局课题 |
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| 摘 要： | ![]()
Objective To observe The liver lipogenic gene expression of animal model of phlegm and dampness syndrome. Methods According to the theory "Obese people have much more phlegm and dampness", the animal model of phlegm and dampness was built by high fat feeding. After 10 weeks' high fat feeding, we examined liver HE slice, the level of lipids in the normal and model group rats .The liver lipogenic gene expression including LXRα, SREBP-1c, and FAS were detected by fluorescence real time quantative PCR. Results Compared with that of the normal group rat, there was increasing lipids both in serum and liver in the model rats. There was typical appearance of fatty accumulation in the liver cells examined by liver HE staining. The expression of SREBP-Ic and FAS was much higher in phlegm and dampness group than that in the normal group, although there was no difference in the expression of LXRα. Conclusion The fatty accumulation of liver cell in phlegm and dampness group has a close relation to the enhancement of the liver lipoganic gene expression.
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| 关 键 词： | 痰湿证模型 高脂饮食 固醇调节元件结合蛋白-1c 脂肪酸合成酶 |
The Liver Lipogenic Gene Expression of Animal Model of Phlegm and Dampness Syndrome |
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| Abstract: | ![]()
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| Keywords: | Syndrome of phlegm and dampnessHigh fat feedingSREBP-1c: FAS |
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