利多卡因、胞二磷胆碱治疗急性胰腺炎的实验研究

目的　探讨利多卡因、胞二磷胆碱对急性胰腺炎 (AP)的治疗作用。方法　在 2 4只wistar大鼠胰管内逆行注入牛胆汁酸钠 ,造成AP模型后 ,随机分成治疗组和对照组 ,治疗组大鼠以利多卡因 (2mg/kg)和胞二磷胆碱 (2mg/kg)于尾静脉缓慢静注 ,3h后再重复 1次 ,直至实验结束 ;对照组以同样方法及间隔时间给予生理盐水 (50ml/kg)动态观察各组指标的变化。 结果　对照组大鼠血清超氧化物歧化酶 (SOD)含量明显低于治疗组 (P <0 .0 5) ;血清淀粉酶明显高于治疗组 (P <0 .0 1 ) ;2 4h病死率和存活时间明显短于治疗组 (P<0 .0 5)。结论　利多卡因 ,胞二磷胆碱对大鼠急性胰腺炎有治疗作用

LIDOCAINE HYDROCHLORIDE AND CITICOLINE IN ACUTE NECROTIZING PANCREATITIS

Objective To study the therapeutic effect of Lidocaine Hydrochloride and citicoline in acute necrotizing pancreatitis(ANP). Methods 24 wistar rats were randomly divided into therapeutic group and control group after induction of ANP by retograde introductal injection of 5 percent sodium taurocholate .The rats of therapeutic group received intravenous Lidocaine Hydrochloride (2mg/kg) and citicoline (2mg/kg) every 3 hours until the end of experiment; those of control group received saline(5.0ml/kg) in the same way. Results Compared with therapeutic group, SOD level were significantly lower in control group (P<0.05);serum amylase level were significantly higher in control goup(P<0.01);the mortality in 24 hours was significantly higher and survival time was significantly shorter in control group (P<0.05). Conclusion Lidocaine Hydrochloride and citicoline has therapeutical effect on ANP in rats.