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| 卡马西平缓释片及其药物动力学研究 | |
| 引用本文： | 余自成 张静华. 卡马西平缓释片及其药物动力学研究[J]. 中国医药工业杂志, 1996, 27(11): 491-494 |
| 作者姓名： | 余自成 张静华 |
| 作者单位： | 上海医科大学华山医院药剂科，上海第二医科大学瑞金医院药剂科 |
| 摘 要： | 利用羟丙基甲基纤维素、乙基纤维素及甲基纤维素为骨架材料制备了卡马西平缓释片。该缓释片体外释药符合一级速率过程。家兔及人体内药动学研究证实其具有较好的缓释效果。 |
| 关 键 词： | 卡马西平，缓释片，药物动力学 |
PHARMACOKINETICS INVESTIGATION ON SUSTAINED RELEASE CARBAMAZEPINE TABLETS |
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| YU Zi-Cheng,ZHANG Jing-Hua,WANG Hong-Tu,ZHONG Ming-Kang,ZHANG Li-Li. PHARMACOKINETICS INVESTIGATION ON SUSTAINED RELEASE CARBAMAZEPINE TABLETS[J]. , 1996, 27(11): 491-494 | |
| Authors: | YU Zi-Cheng ZHANG Jing-Hua WANG Hong-Tu ZHONG Ming-Kang ZHANG Li-Li |
| Abstract: | The sustained release carbamazepine tablets(SR-CBZ) were prepared using HPMC,EC and MC as matrix.In vitro dissolution of SR-CBZ could be best described by the first order kinetics.The pharmacokinetics of SR-CBZ were studied in rabbits and in healthy volunteers,in vivo test verified that SR-CBZ possessed good sustained release efficacy. |
| Keywords: | carbamazepine sustained release tablet pharmacokinetics |
| 本文献已被 CNKI 维普 等数据库收录！ | |