Survivin在乳腺癌中的表达及临床意义

目的 检测乳腺癌组织中Survivin的表达,结合10年预后随访结果,探讨Survivin的表达的临床意义.方法 采用免疫组织化学SP法及图像分析技术检测和分析60例乳腺癌、20例乳腺纤维腺瘤和20例正常乳腺组织中Survivin的表达,所有乳腺癌病例均做10年预后随访,并结合肿瘤的病理学特征和临床随访资料分析.结果 (1)60例乳腺癌中Survivin表达明显高于乳腺纤维腺瘤和正常乳腺组织(P＜0.01);(2)乳腺癌中Survivin表达与临床分期、腋淋巴结转移有关(P＜0.05);与患者年龄、肿瘤大小、组织学类型、病理分级均无关;(3)乳腺癌中Survivin与预后生存年限的表达呈显著负相关(P＜0.05).结论 Survivin在乳腺癌组织中表达上调,对乳腺癌发生和发展起重要作用.Survivin与乳腺癌的预后呈负相关.

Expression and significe of Survivin in breast carcinoma

Objective To study the expression of Survivin in breast carcinoma combined with prognosis of ten-year follow-up.Methods The expression of Survivin was investigated by immunohistochemistry in 60 cases of breast cancer and 20 tumor surrounding tissue.All the cases were performed with prognosis of tenyear follow-up.Results The expression rate of Survivin in breast carcinoma(68.3%)was higher than that in fibroadenoma of bast tissue(25%)(χ2=20.03,P＜0.01).Survivin didn't experss in tumor surrounding tissue.There Was no relationship among the expression of Survivin and the histological differentiation,clinical staging,and lymph node metastasis of breast carcinoma.The expression of Survivin was correlated with the survival years of patients.Conclusion The expression of Survivin was up-regulated in breast carcinoma,which indicated that survivin may play an important role of the genesis and development of breast cancer,but it may play negative correlated with breast carcinoma.