肺胀方辅助治疗AECOPD疗效及对营养状态的影响

目的 观察肺胀方辅助治疗慢性阻塞性肺疾病急性加重期（acute exacerbation of chronic obstructive pulmonary disease,AECOPD）疗效及对营养状态的影响。方法 选取2020年5月至2021年5月绍兴市中医院收治住院的AECOPD患者80例,采用随机数字表法分为对照组和研究组,每组40例。对照组给予西医常规治疗,研究组在对照组基础上辅以肺胀方治疗,疗程均为2周。比较两组临床疗效、治疗前后中医证候总评分、营养状况指标[体质量指数（body mass index,BMI）、肱三头肌皮褶厚度（triceps skinfold thickness,TSF）及上臂肌围（arm muscle circumference,AMC）]、动脉血气指标[动脉氧分压（partial pressure of arterial oxygen,PaO2）及二氧化碳分压（partial pressure of carbon dioxide,PaCO2）]和肺功能指标[第1秒用力呼气容积（forced expiratory volume in one second,FEV1）和用力肺活量（forced vital capacity,FVC）]水平变化,以及不良事件发生情况。结果 研究组的治疗总有效率（92.50%）明显高于对照组（65.00%）,差异有统计学意义（P<0.05）。治疗后,两组中医证候总积分均显著降低,差异有统计学意义（P<0.05）;营养状况相关指标也有不同程度改善,且研究组优于对照组,差异有统计学意义（P<0.05）;研究组的PaO2、FEV1和FVC水平均显著高于对照组,PaCO2水平显著低于对照组,差异均有统计学意义（P<0.05）。治疗期间,两组均无严重不良事件发生,差异无统计学意义（P>0.05）。结论 临床以肺胀方辅助治疗AECOPD疗效较好,可缓解患者临床症状,改善患者的动脉血气指标水平、肺功能,以及治疗期间患者的营养状态,该联合方案安全性较高。

Effect of Lung Distension Square as adjuvant treatment in COPD exacerbations and analysis of its effect on nutritional status

Objective To observe the efficacy and effect on nutritional status of adjunctive treatment with a Lung Distension Square in acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods A total of 80 patients admitted to Shaoxing Chinese Hospital with acute exacerbation of COPD from May 2020 to May 2021 were selected and divided into the control group and the study group according to random number table method, with 40 cases in each group. The control group was given routine treatment with western medicine, and the study group was supplemented with treatment by Lung Distension Square, the course of which in both groups was two weeks. The clinical outcomes of the two groups were compared before and after treatment, and changes in the levels of traditional Chinese medicine (TCM) syndrome sum score, nutritional status indexes [body mass index (BMI), triceps skinfold thickness (TSF), and upper arm muscle circumference (AMC)], arterial blood gas indexes [partial pressure of arterial oxygen (PaO2) and partial pressure of carbon dioxide (PaCO2)], and pulmonary function indexes [forced expiratory volume in one second (FEV1) and forced vital capacity (FVC)] were observed, adverse event occurrence was counted last. Results The total effective rate of treatment in the study group (92.50%) was significantly higher than that in the control group (65.00%), with a statistically significant difference (P<0.05). After treatment, the total scores of TCM syndromes in the two groups were significantly reduced (P<0.05), and the nutrition status related indexes were also improved to different degrees, and the study group showed a more significant improvement than the control group (P<0.05). After treatment, patients in the study group had significantly higher levels of PaO2, FEV1, and FVC, but lower levels of PaCO2 (P<0.05). During treatment, no serious adverse events occurred in two groups, and the difference was not statistically significant (P>0.05). Conclusion The treatment of AECOPD with the assistance of lung distension square was better, which could relieve the patients'' clinical symptoms and improve the patients'' arterial blood gas indicator levels, lung function, as well as the patients'' nutritional status during the treatment, and the safety of this combination regimen was high.