| 奎的平与氯氮平治疗首发精神分裂症对照研究 |
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| 引用本文： | 王永彬,王东平,阎春玲. 奎的平与氯氮平治疗首发精神分裂症对照研究[J]. 临床心身疾病杂志, 2003, 9(3): 154-156 |
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| 作者姓名： | 王永彬 王东平 阎春玲 |
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| 作者单位： | 新乡医学院第二附属医院 453002(河南·新乡)(王永彬，王东平)，新乡医学院第二附属医院 453002(河南·新乡)(阎春玲) |
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| 摘 要： | 目的 了解奎的平与氯氮平对精神分裂症的疗效及不良反应的差别。方法 选择符合DSM-Ⅳ和CCMD-2-R关于精神分裂症诊断标准的患者,且阳性和阴性症状量表(PANSS)评分>60分。共108例患者完成了8w的研究,其中奎的平组55例,氯氮平组53例。在治疗前及治疗后1、2、4、6w分别评定PANSS,CGI及ESPS量表。结果 奎的平对精神病性症状的总有效率与氯氮平组相比无明显差异。但奎的平对抑郁症状、攻击行为和敌意、认知功能障碍的疗效明显好于氯氮平,两组有显著性差异。在8w的治疗过程中,奎的平组的总体副反应,特别是行为障碍和肌张力障碍明显少于氯氮平组,两组有显著性差异。结论 奎的平是一种较理想的抗精神病药,对首发精神分裂症有较好的疗效和耐受性,并且起效较快,安全性高,值得临床推广使用。
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| 关 键 词： | 奎的平 氯氮平 首发精神分裂症 疗效 |
A control study of quetiapine and clozapine in the treatment of first - episode schizophrenia. |
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| Wang Yong - bin,Wang Dong - ping,Yan Chun - ling. A control study of quetiapine and clozapine in the treatment of first - episode schizophrenia.[J]. Journal of Clinical Psychosomatic Diseases, 2003, 9(3): 154-156 |
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| Authors: | Wang Yong - bin Wang Dong - ping Yan Chun - ling |
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| Abstract: | Objective To probe efficacy and side effect of quetiapine and clozapine in the treatment of first - episode schizophrenia. Methods One hundred and eight first - episode schizophrenics were randomly treated with quetiapine or clozapine. Their therapeutic effects were evaluated with PANSS, CGIGI and ESPS. Results The therapeutic effect of quetiapine was better and side effect milder than those of clozapine. Conclusion Quetiapine is preferred as an ideal agent in the treatment of first - episode schizophrenia. |
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| Keywords: | quetiapine clozapine first- episode schizophrenia efficacy |
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