| 梗阻性黄疸大鼠血浆NO与ET改变及其意义 |
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| 引用本文： | 刘祥德,何振平,别平.梗阻性黄疸大鼠血浆NO与ET改变及其意义[J].第三军医大学学报,2000,22(8):731-733. |
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| 作者姓名： | 刘祥德 何振平 别平 |
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| 作者单位： | 第三军医大学附属西南医院肝胆外科中心、西南肝胆外科医院,重庆,400038 |
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| 摘 要： | 目的 探讨大鼠梗阻性黄疸时血浆ＮＯ和ＥＴ的改变及其意义。方法 胆总管结扎法建立梗阻性黄疸模型，用放射免疫分析法和比色法测定血浆ＮＯ和ＥＴ的水平，生理记录仪测定心率（ＨＲ）、平均动脉压（ＭＡＰ）、心输出量（ＣＯ）。结果 胆总管结扎组（ＢＤＬ组）大鼠血浆ＮＯ含量明显增高，ＥＴ含量下降，平均动脉压（ＭＡＰ）下降，心率（ＨＲ）减慢，心输出量（ＣＯ）增加，与ＳＯ组、Ｎ组相比，ＳＯ组与Ｎ组之间差异不明显。结论
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| 关 键 词： | 一氧化氮 内皮素 梗阻性黄疸 血流动力学 大鼠 |
Changes of plasma nitric oxide and endothelin in obstructive jaundice in rats |
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| LIU Xiang-de,HE Zhen-ping,BIE Ping.Changes of plasma nitric oxide and endothelin in obstructive jaundice in rats[J].Acta Academiae Medicinae Militaris Tertiae,2000,22(8):731-733. |
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| Authors: | LIU Xiang-de HE Zhen-ping BIE Ping |
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| Abstract: | Objective To study the changes of nitric oxide(NO) and endothelin(ET) in obstructive jaundice in rats. Methods Plasma concentration of NO and ET were determined in bile duct ligated (BDL) rats and control rats with colorimetry and radioimmunoassay. HR, MAP and CO were measured with kymography. Results NO level in BDL group was higher than in control rats( P <0.01), and the plasma level of ET was lower in BDL group than in control rats 10 days after bile duct ligation (P < 0.05). The decreased MAP and HR and increased CO were observed in BDL group. Conclusion The increase of NO and decrease of ET might play roles in systemic hemodynamic changes of obstructive jaundic. |
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| Keywords: | nitric oxide endothelin bile duct obstruction hemodynamics |
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