| 中西药合用对帕金森病大鼠旋转行为的影响 |
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| 引用本文： | 何建成,袁灿兴,卫洪昌,陈汝兴.中西药合用对帕金森病大鼠旋转行为的影响[J].中西医结合学报,2003,1(4):293-295. |
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| 作者姓名： | 何建成 袁灿兴 卫洪昌 陈汝兴 |
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| 作者单位： | 1. 上海中医药大学中医诊断学教研室,上海,200032
2. 上海中医药大学附属龙华医院神经内科,上海,200032 |
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| 基金项目： | 上海市教委科研基金资助项目 (No .98C0 8) |
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| 摘 要： | 目的 观察中西药合用对帕金森病(Parkinson disease，PD)大鼠旋转行为的影响。方法 采用6羟多巴胺注射于脑右侧黑质造成偏侧帕金森病模型，并用滋补肝肾、通络解毒的中药以及西药美多巴进行治疗，同时设立美多巴对照组，观察中西药合用对PD大鼠旋转行为的影响。结果 中西药合用可使模型大鼠的旋转圈数明显减少。结论 中西药合用能明显改善PD模型大鼠的旋转行为。
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| 关 键 词： | 西药 帕金森病 大鼠 中药 药物 治疗 PD |
| 文章编号： | 1672-1977(2003)04-0293-03 |
| 修稿时间： | 2003年3月20日 |
Effect of Chinese and western medicine integration on spinning behavior of rats with Parkinson disease |
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| HE Jian-Cheng ,YUAN Can-Xing ,WEI Hong-Chang ,CHEN Ru-Xing.Effect of Chinese and western medicine integration on spinning behavior of rats with Parkinson disease[J].Journal of Chinese Integrative Medicine,2003,1(4):293-295. |
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| Authors: | HE Jian-Cheng YUAN Can-Xing WEI Hong-Chang CHEN Ru-Xing |
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| Institution: | Department of Traditional Chinese Medicine Diagnosis, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China. hejc8@yahoo.com.cn |
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| Abstract: | OBJECTIVE: To observe the effect of Chinese and western medicine integration on the spinning behavior of rats with Parkinson disease. METHODS: Model of the lateral Parkinson disease was made with injection of 6-hydroxydopamine (6-OHDA) into the black substance of the right side of the brain, and the model rats were treated with madopar and Chinese herbs for nourishing the liver and kidney, clearing collaterals and detoxification. The rat's spinning behavior was observed, and was compared with the normal control group, madopar group and sham-operation group at the same time. RESULTS: Chinese and western medicine integration could obviously reduce the spinning circles of the rats. CONCLUSION: Chinese and western medicine integration can significantly improve the spinning behavior of the model rats. |
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| Keywords: | drugs Chinese herbal madopar Parkinson disease neurobehavioral manifestations drug therapy |
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