| Inhibition of haringtonine-induced apoptosis by tetradecanoylphorbol acetate in human leukemia HL-60 |
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| 引用本文： | 孟凡宏,何琪杨,张鸿卿,薛绍白. Inhibition of haringtonine-induced apoptosis by tetradecanoylphorbol acetate in human leukemia HL-60[J]. Acta pharmacologica Sinica, 1997, 0(5) |
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| 作者姓名： | 孟凡宏 何琪杨 张鸿卿 薛绍白 |
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| 作者单位： | 北京师范大学生物系 |
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| 摘 要： | 目的：研究十四酰佛波乙酸酯（ＴＡ）预处理后，三尖杉酯碱（Ｈａｒ）和喜树碱（Ｃａｍ）诱导人白血病ＨＬ６０细胞凋亡的变化．方法：染色质凝集观察，流式细胞术，ＤＮＡ琼脂糖凝胶电泳和点杂交．结果：ＴＡ２００ｎｍｏｌ·Ｌ－１预处理ＨＬ６０细胞６ｈ，明显抑制Ｈａｒ０１ｍｇ·Ｌ－１作用３ｈ诱导的细胞凋亡，但只部分抑制Ｃａｍ０２ｍｇ·Ｌ－１作用３ｈ诱导的细胞凋亡．ＴＡ预处理ＨＬ６０细胞明显降低ｃｍｙｃ基因的表达．结论：ＴＡ明显抑制由Ｈａｒ和部分抑制由Ｃａｍ诱导的ＨＬ６０细胞凋亡，而且ＴＡ预处理的细胞中ｃｍｙｃ基因表达明显下降，这可能导致了对诱导细胞凋亡的抑制．
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| 关 键 词： | HL-60细胞；细胞凋亡；十四酰佛波乙酸酯；三尖杉酯碱类；喜树碱；myc基因 |
Inhibition of harringtonine induced apoptosis by tetradecanoylphorbol acetate in human leukemia HL 60 cells |
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| MENG Fan Hong,HE Qi Yang,ZHANG Hong Qing,XUE Shao Bai. Inhibition of harringtonine induced apoptosis by tetradecanoylphorbol acetate in human leukemia HL 60 cells[J]. Acta pharmacologica Sinica, 1997, 0(5) |
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| Authors: | MENG Fan Hong HE Qi Yang ZHANG Hong Qing XUE Shao Bai |
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| Affiliation: | MENG Fan Hong,HE Qi Yang,ZHANG Hong Qing,XUE Shao Bai 2 |
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| Abstract: | |
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| Keywords: | HL 60 cells apoptosis tetradecanoylphorbol acetate harringtonines camptothecin myc genes |
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