| 汉族人群白细胞介素-2基因多态性与鼻咽癌风险的关系 |
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| 引用本文： | 杜冰,文彬,木尔扯尔. 汉族人群白细胞介素-2基因多态性与鼻咽癌风险的关系[J]. 西部医学, 2010, 22(7): 1188-1190 |
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| 作者姓名： | 杜冰 文彬 木尔扯尔 |
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| 作者单位： | 1. 川北医学院,法医物证学教研室,四川,南充,637000
2. 川北医学院,病理学教研室,四川,南充,637000 |
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| 基金项目： | 四川省卫生厅资助项目，四川省南充市科技局资助项目 |
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| 摘 要： | 目的研究四川汉族人群白细胞介素-2基因（IL-2）-330T/G及＋114G/T基因多态性与鼻咽癌风险的关系。方法采用病例对照研究方法,PCR-RFLP检测180例汉族人和150例鼻咽癌患者IL-2-330T/G、＋114G/T的多态性分布及与鼻咽癌风险的关系。结果病例组和对照组两多态性位点基因型频率分布无显著性差异（P〉0.05）,两多态性位点未增加个体患鼻咽癌的风险（P〉0.05）。结论 IL-2-330T/G、＋114G/T多态性与鼻咽癌易感性无关。
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| 关 键 词： | 鼻咽癌 白细胞介素-2基因 遗传多态性 |
Relationship of genetic polymorphisms of interleukin-2 and risk of nasopharyngeal carcinoma in Han population |
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| DU Bing,WEB Bin,MUER Che-er. Relationship of genetic polymorphisms of interleukin-2 and risk of nasopharyngeal carcinoma in Han population[J]. , 2010, 22(7): 1188-1190 |
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| Authors: | DU Bing WEB Bin MUER Che-er |
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| Affiliation: | DU Bing,WEB Bin,MUER Che-er(Department of Forensic Biology,North Sichuan Medical College,Nanchong 637000,Sichuan,China) |
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| Abstract: | Objective To investigate the relationship of the polymorphisms of interleukin-2（IL-2）-330T/G,＋114G/T polymorphisms and the risk of nasopharyngeal carcinoma in Han population from Sichuan,China.Methods A case-control study was conducted involving 150 nasopharyngeal carcinoma patients and 180 healthy controls to investigate the association between the polymorphism of IL-2-330T/G,＋114G/T and the risk of nasopharyngeal carcinoma.The genotypes were determined by PCR-RFLP technique.Results There was no significant difference in the genotypes of IL-2-330T/G,＋114G/T polymorphisms between cases and controls（P〉0.05）.In addition,genotypic frequency was not associated with nasopharyngeal carcinoma.Conclusion Genetic polymorphisms of IL-2-330T/G,＋114G/T were not associated with susceptibility to nasopharyngeal carcinoma. |
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| Keywords: | Nasopharyngeal carcinoma Interleukin-2 gene Genetic polymorphism |
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