二至丸对阴虚模型神经内分泌免疫网络调节作用的研究

观察二至丸对阴虚动物神经－内分泌－免疫网络的影响。方法：通过阴虚大鼠血皮质醇、胰岛素、睾酮、胆固醇、β－内啡吠含量及胸腺和肾上腺重量等相关指标，并观察药物对小鼠ＮＫ活性和刀豆素Ａ诱导的小鼠脾淋巴细胞增殖反应，说明二至丸对阴虚模型神经内分泌免疫网络的调节作用。

Study on Erzhi Pill Effects on Neuro-Endocrinologic-Immuno Network of Animal of Deficiency of Yin

OBJECTIVE: To investigate Erzhi Pill effect on Neuro-Endocrinologic-Immuno network of animal of deficiency of Yin. METHOD: In the experiment through the determination of hemotic cortisol, insulin, testosterone, beta-endorphin, cholesterol, weight of adrenal and thymus, ConA-induced, spleelymphocyte proliferation and activity of natural killer cells (NKC). The changes of the animals of deficiency of Yin and the effects of the Erzhi Pill were investigated. RESULT: It showed that rats of deficiency of Yin, their hemotic, cortisol, insulin, testosterone, beta-endorphin, weight of adrenal and thymus decreased, cholesterol increased and mouse of deficiency of Yin, their lymphocyte proliferation and activity of NKC dcreased, which might be modulated with Erzhi Pill. Erzhi Pill could improve hemotic cortisol, insulin, testosterone, beta-endorphin, weight of adrenal and thymus, reduce hemotic cholesterol, improve lymphocyte proliferation and activity of NKC. CONCLUSION: This principle could improve animals of deficiency of Yin regulating Neuro-Endocrinologic-Immuno network and keeping homeostais.