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| 血清抗C1q抗体在系统性红斑狼疮疾病活动性判断及狼疮肾炎诊断中的价值 | |
| 引用本文： | 冯江超,青玉凤,周京国. 血清抗C1q抗体在系统性红斑狼疮疾病活动性判断及狼疮肾炎诊断中的价值[J]. 免疫学杂志, 2010, 0(3) |
| 作者姓名： | 冯江超 青玉凤 周京国 |
| 作者单位： | 川北医学院附属医院肾脏内科;川北医学院风湿免疫研究所; |
| 摘 要： | 目的探讨抗C1q抗体(C1qAb)在系统性红斑狼疮(SLE)活动性及狼疮肾炎(LN)诊断和疾病活动性判断中的价值。方法采用酶联免疫吸附法检测SLE患者(n=89)、疾病对照组(n=56)和正常对照组(n=42)血清中的抗C1q抗体阳性率,并与SLE患者临床实验室指标﹑活动性评分进行分析。结果 C1qAb的阳性率在SLE患者中显著高于疾病对照组和正常对照组患者(P<0.05);C1qAb阳性的SLE患者肾损发生率、活动性狼疮发生率及抗dsDNA抗体的阳性率均高于C1qAb阴性患者(P<0.05);C1qAb与SLEDAI活动性评分、抗核小体抗体(anti-nucleosome antibody,AnuA)及抗dsDNA抗体呈正相关(P<0.05)。结论抗C1q抗体对SLE的诊断和疾病活动性判断有重要价值;抗C1q抗体参与了SLE肾脏损害的发病机制。 |
| 关 键 词： | 抗C1q抗体 系统性红斑狼疮 狼疮性肾炎 抗dsDNA抗体 抗核小体抗体 |
Significance of anti-C1q antibody in diagnosis of systemic lupus erythematosus with lupus flare and lupus nephritis |
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| FENG Jiangchao,QING Yufeng,ZHOU Jingguo. Significance of anti-C1q antibody in diagnosis of systemic lupus erythematosus with lupus flare and lupus nephritis[J]. Immunological Journal, 2010, 0(3) | |
| Authors: | FENG Jiangchao QING Yufeng ZHOU Jingguo |
| Affiliation: | FENG Jiangchao,QING Yufeng,ZHOU Jingguo Department of Nephrology,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,China |
| Abstract: | In this study,we aimed to explore the value of anti-C1q antibody(C1qAb) in diagnosis of systemic lupus erythematosus(SLE) with lupus flare and lupus nephritis.By using ELISA,we measured the anti-C1qAb in sera from 89 SLE patients,56 patients suffered with other rheumatic disease,and 42 healthy cases.We found that the positive rate of anti-C1qAb in SLE patients was much higher than that in patients with other rheumatic disease and healthy cases(59.6% vs 10.7%;59.6% vs 9.5%).Furthermore,the prevalence of rena... |
| Keywords: | Anti-C1q antibody Systemic lupus erythematosus Lupus nephritis Anti-dsDNA antibody Anti-nucleosome antibody |
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