Genetic variants in the calpain-10 gene and the development of type 2 diabetes in the Japanese population |
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| Authors: | Naoko Iwasaki Yukio Horikawa Takafumi Tsuchiya Yutaka Kitamura Takahiro Nakamura Yukio Tanizawa Yoshitomo Oka Kazuo Hara Takashi Kadowaki Takuya Awata Masashi Honda Katsuko Yamashita Naohisa Oda Li Yu Norihiro Yamada Makiko Ogata Naoyuki Kamatani Yasuhiko Iwamoto Laura del Bosque-Plata M. Geoffrey Hayes Nancy J. Cox Graeme I. Bell |
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| Affiliation: | (1) Diabetes Center, Tokyo Women!["rsquo"]("/content/9w9ny73dlbtd58en/xlarge8217.gif") s Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan;(2) Laboratory of Molecular Genetics, Department of Cell Biology, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan;(3) Departments of Biochemistry and Molecular Biology, Human Genetics and Medicine, The University of Chicago, Chicago, Illinois, USA;(4) Department of Statistical Genetics, Institute of Rheumatology, Tokyo Womens Medical University, Tokyo, Japan;(5) Division of Molecular Analysis of Human Disorders, Department of Bio-Signal Analysis, Yamaguchi University Graduate School of Medicine, Ube, Japan;(6) Division of Molecular Metabolism and Diabetes, Department of Internal Medicine, Tohoku University, Sendai, Japan;(7) Department of Metabolic diseases, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo, Japan;(8) Division of Endocrinology and Diabetes, Department of Medicine, Saitama Medical School, Saitama, Japan;(9) Shiseikai Daini Hospital, Tokyo, Japan;(10) Seijin Igaku Medical Clinic, Tokyo, Japan;(11) Department of Internal Medicine, Fujita Health University School of Medicine, Aichi, Japan |
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| Abstract: | ![]()
Variation in the gene encoding the cysteine protease calpain-10 has been linked and associated with risk of type 2 diabetes. We have examined the effect of three polymorphisms in the calpain-10 gene (SNP-43, Indel-19, and SNP-63) on the development of type 2 diabetes in the Japanese population in a pooled analysis of 927 patients and 929 controls. We observed that SNP-43, Indel-19, and SNP-63 either individually or as a haplotype were not associated with altered risk of type 2 diabetes with the exception of the rare 111/221 haplogenotype (odds ratio (OR) =3.53, P=0.02). However, stratification based on the median age-at-diagnosis in the pooled study population (<50 and  50 years) revealed that allele 2 of Indel-19 and the 121 haplotype were associated with reduced risk in patients with later age-at-diagnosis (age-at-diagnosis 50 years OR=0.82 and 0.80, respectively; P=0.04 and 0.02). Thus, variation in the calpain-10 gene may affect risk of type 2 diabetes in Japanese, especially in older individuals.Naoko Iwasaki, Yukio Horikawa and Takafumi Tsuchiya contributed equally to this work. |
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| Keywords: | Association study Age-at-diagnosis Calpain-10 Genetics Polymorphism Type 2 diabetes |
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