精神分裂症和心境障碍混合家系5-HTR 6基因多态性的关联分析

目的 在中国汉族人群精神分裂症和心境障碍混合家系中探讨五羟色胺6受体（5-HTR6）基因267C／T多态性与精神分裂症、心境障碍的关联性。方法 采用聚合酶链反应一限制性片断长度多态（PCR—RFLP）技术对67例精神病混合家系患者及其父母进行5-HTR6基因267C／T多态性检测，并予以传递不平衡检验（TDT）。结果 患者组与父母组之间，5-HTR6基因267C／T多态性等位基因分布（χ^2=2．70，v=1，P〉0．05）和基因型分布（χ^2=2．97，v=2，P〉0．05）无明显差异，5-HTR6基因267C／T多态性与精神分裂症（χ^2=5．16，P〈0．05）存在关联，但与心境障碍（χ^2=2．17，P〉0．05）无关联。结论 在中国汉族人群中5-HTR6基因或邻近基因可能是精神分裂症易患基因之一，但可能不是心境障碍的易患基因。

Association study between 5-HTR 6 gene polymorphisms with schizophrenia and mood disorders

Objective: To explore the relationships between serotonin 6 receptor (5 - HTR 6) gene polymorphisms and schizophrenia, mood disorders in the mixed pedigrees of Chinese Han population. Methods: The 5 - HTR 6 SNPs 267C/T were genotyped by applying polymerase chain reaction - restriction fragment length polymorphism ( PCR - RLFP) technique in 67 mixed - families of schizophrenia and mood disorders, then transmission disequilibrium test (TDT) was performed. Results: There were no significant difference in alleles( X2 = 2. 70, v = 1, P > 0. 05 ) and genotypes ( X2 = 2. 97, v = 2, P > 0. 05 ) distribution between patients and their parents. The SNPs 267C/T was associated with schizophrenia( X2 =5. 16, P < 0. 05) , but not associated with mood disorder (X2 = 2. 17 ,P >0. 05). Conclusion: The 5 - HTR 6 gene or neighboring gene may be one of common susceptible genes for schizophrenia, but not for mood disorders in Chinese Han population.