交联透明质酸钠凝胶重金属总量检测方法比较与探讨

目的 探究交联透明质酸钠凝胶重金属总量的检测方法.方法 按照《中国药典》2020年版0821重金属检测法第三法(硫化钠法)和第二法(炽灼残渣法)进行重金属限量检测,追踪实验过程并进行试验结果分析.结果 发现在对交联透明质酸钠凝胶进行重金属限量检测时第三法(硫化钠法)无法正确反映出产品中重金属的限量值,第二法(炽灼残渣法...

Comparison and discussion on the detection methods of heavy metals in crosslinked sodium hyaluronate gel

Objective To explore the method of detecting the total amount of heavy metals in crosslinked sodium hyaluronate gel.Methods In this study, two representative sodium hyaluronate gel products from different manufacturers were selected. According to the heavy metal detection method of Pharmacopoeia of the People''s Republic of China (2020 edition) 0821, heavy metal limit detection was carried out by the third method (sodium sulfide method) and the second method (ignition residue method), track the experimental process and analyze the experimental results.Results The experimental phenomena showed that the third method (sodium sulfide method) could not correctly reflect the limit value of heavy metals in the product, the second method (ignition residue method) is more appropriate.Conclusion The crosslinked sodium hyaluronate gel after cauterization and acidification can be used to investigate the total amount of heavy metals in the products.