The disomy for chromosome IV and the spontaneous rho- mutability in Saccharomyces cerevisiae |
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| Authors: | A. B. Devin Natalia A. Koltovaya Nadezhda I. Cheryomukhina |
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| Affiliation: | (1) Institute of Molecular Genetics, Academy of Sciences of the USSR, Academician Kurchatov Square, D-182 Moscow, USSR;(2) The Joint Institute of Nuclear Research, Dubna, Moscow Region, USSR |
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| Abstract: | Summary The disomy for chromosome IV in the strains studied led to: i) a reduction in the red pigmentation of ade1 mutant colonies; ii) a decrease of the spontaneous rho– mutant frequency, and iii) an impairment of sporulation in hybrids descended from disomic parents. The nuclear srm1 mutation decreasing the spontaneous rho– mutability promoted the spontaneous extra chromosome loss in the disomes for chromosome IV. This result suggests a close connexion between the spontaneous rho– mutability and mitotic chromosome stability. |
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| Keywords: | Yeast Disomy for chromosome IV Mitochondrial rho– mutability Mitotic chromosome loss |
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