Discovery of a novel HLA‐DRB1*04:05 variant,DRB1*04:05:15, in a Taiwanese and the probable HLA haplotype in association with DRB1*04:05:15 |
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| Authors: | K. L. Yang S. K. Lee P. Y. Lin |
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| Affiliation: | 1. Laboratory of Immunogenetics and Cord Blood Bank, Buddhist Tzu Chi General Hospital, Buddhist Tzu Chi Stem Cells Centre and Marrow Donor Registry, Buddhist Compassion Relief Tzu Chi Foundation, , Hualien, Taiwan;2. Department of Medical Biotechnology, Buddhist Tzu Chi University, Buddhist Compassion Relief Tzu Chi Foundation, , Hualien, Taiwan |
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| Abstract: | Here, we report a novel HLA‐DRB1*04 allele, DRB1*04:05:15, found in a Taiwanese unrelated volunteer bone marrow hematopoietic stem cell donor by a sequence‐based typing (SBT) method. The DNA sequence of DRB1*04:05:15 is identical to the sequence of DRB1*04:05:01 in exon 2, except the nucleotide at the position 198 where C is substituted by T (TAC→TAT at codon 37). Due to the silent mutation, the nucleotide replacement generated no amino acid variation in comparison with DRB1*04:05:01. We postulate the allele DRB1*04:05:15 was probably derived from DRB1*04:05:01 via a nucleotide point mutation event. The probable HLA‐A, ‐B, ‐C, ‐DRB1 and ‐DQB1 haplotype in association with DRB1*04:05:15 may be deduced as A*02:01‐B*48:01‐C*08:03‐DRB1*04:05:15‐DQB1*04:01. |
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