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Lysophospholipase D activity exists in the urine to catalyse the formation of lysophosphatidic acid. |
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| Authors: | Ryunosuke Ohkawa Nobuo Hisano Kazuhiro Nakamura Shigeo Okubo Hiromitsu Yokota Yutaka Yatomi |
| Affiliation: | 1Department of Clinical Laboratory The University of Tokyo Hospital 2Department of Internal Medicine Japanese Red Cross Medical Center Tokyo, Japan |
| Abstract: | Sir, Lysophosphatidic acid (LPA) has been suggested to be involvedin the pathogenesis of a number of disease states, includingcancer and atherosclerosis, through its induction of a widerange of (patho)physiological events, such as cellular survival,proliferation, migration, change in morphology and extracellularmatrix deposition [1,2]. These actions of LPA are believed tobe mediated via specific cell-surface G protein-coupled receptorsand the downstream intracellular signalling pathways [1,2].The important role of LPA is |
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