前列腺癌组织中ILK和E-Cadherin的表达及其意义

目的　探讨整合素连接激酶 (ILK )、上皮细胞钙黏素 (E cad)在前列腺癌组织中的表达及其意义。方法　应用免疫组织化学 (S P)方法检测 5 0例前列腺癌及 16例良性前列腺增生组织中ILK、E cad蛋白的表达。结果　前列腺癌组织中ILK、E cad阳性表达率分别为 46.0 % (2 3 /5 0 )、5 0 .0 % (2 5 /5 0 )。随肿瘤细胞病理分级、临床分期程度的增高 ,ILK阳性表达率增高而E cad表达降低 ,各组间均有显著性差异 (P <0 .0 5或P <0 .0 1)。与良性前列腺增生组织中的阳性表达率 10 0 .0 % (16/16)和 6.2 % (1/16)比较 ,均有显著性差异 (P <0 .0 5 )。结论　ILK、E cad蛋白异常表达在前列腺癌的恶性进展中起重要作用 ,ILK高表达或激活可能是E cad低表达或缺失的原因之一 ,联合检测ILK、E cad表达有利于判断病期及预后。

Expression of Integrin-linked Kinase and E-cadherin in Prostate Cancer and Its Significance

Objective To investigate the expression of Integrin-linked Kinase(ILK) and E-cadherin(E-cad) in primary prostate cancer and its clinical significance.Methods ILK and E-cad protein expression in paraffin-embedded tissues from 50 prostate cancer and 16 benign prostatic hyptertrophy sample were analysed by immunohisochemical staining.Results The positive rates of ILK and E-cad were 46.0%(23/50) and 50.0%(25/50)in primary prostate cancer,respectively.The higher the tumor grade and clinical stage,the higher the expression of ILK and the lower the expression of E-cad(P<0.05 or P<0.01).But the positive rate in benign prostatic hyptertrophy were 6.2%(1/16 )for E-cad and 100%(16/16) for ILK,showing a significant difference with those in prostate cancer(P<0.05).Conclusion The abnormal expression of ILK and E-cad might plays an important role in the progression of primary prostate cancer.The high expression or up-regulation activation of ILK might inhibite expression of E-cad.Combined detection of ILK and E-cad expression has important significiance for determination of tumor development and prognosis.