Relationship of some open-field behaviors to amygdaloid kindled convulsions in Wistar rats |
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| Authors: | K P Ossenkopp P R Sanberg |
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| Affiliation: | Department of Psychology, University of Western Ontario, London, Ontario N6A 5C2, Canada;Department of Behavioral Biology, Research School of Biological Sciences The Australian National University, Canberra City, A.C.T. Australia |
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| Abstract: | Repeated low-intensity electrical stimulation (kindling) of the amygdala eventually produces convulsive behavior in animals. The present study examined the relationship between behaviors displayed in a novel open-field situation with behavioral characteristics of the kindled clonic convulsion (CC). Wistar rats were given two open-field tests and were subsequently kindled to clonic convulsions. A multiple regression analysis indicated that rats which urinated more often in the open-field tests tended to show longer latencies to CC onset. Thus, open-field urination was a significant predictor of latency to CC onset. It is suggested that an emotionality construct may be related to rate of kindling. |
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| Keywords: | Kindling Amygdala Brain stimulation Convulsions Open-field test Epilepsy |
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