Low-dose tryptophan depletion in recovered depressed women induces impairments in autobiographical memory specificity |
| |
| Authors: | Anneke D. M. Haddad J. Mark G. Williams Sarah F. B. McTavish Catherine J. Harmer |
| |
| Affiliation: | (1) Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford, OX1 3UD, UK;(2) Department of Psychiatry, University of Oxford, Oxford, UK |
| |
| Abstract: | Background Depressed patients perform poorly on tests of autobiographical memory specificity (AMS); this may have negative consequences for other important cognitive abilities, delays recovery from mood episodes, and, in recovered patients, may mediate vulnerability to future episodes. Although the cognitive mechanisms underlying AMS deficits are beginning to be understood, the neurobiological mechanisms remain unclear. Serotonin is implicated in both depression and long-term memory; therefore, temporary lowering of brain serotonin function via acute tryptophan depletion (ATD) offers a means of studying the role of serotonin in autobiographical memory specificity. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
