| 长春西汀治疗血管性痴呆的临床疗效观察 |
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| 引用本文： | 韩锟,贾宁,闵连秋. 长春西汀治疗血管性痴呆的临床疗效观察[J]. 脑与神经疾病杂志, 2007, 15(3): 205-206 |
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| 作者姓名： | 韩锟 贾宁 闵连秋 |
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| 作者单位： | 121001,辽宁锦州,辽宁医学院附属第一医院神经内科;121001,辽宁锦州,辽宁医学院附属第一医院神经内科;121001,辽宁锦州,辽宁医学院附属第一医院神经内科 |
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| 摘 要： | 目的:探讨长春西汀对血管性痴呆(VD)疗效和作用机制。方法:96例VD患者随机分成长春西汀治疗组和胞二磷胆碱对照组,分别在治疗第10、21d进行简易精神状态评分(MMSE)和长谷川评分(1DS),同时测定与记忆有关的乙酰胆碱酯酶(AchE)的活性。结果:长春西汀治疗组患者第21d的MMSE和IDS评分均高于治疗前和一般治疗组(P＜0．01),且长春西汀治疗组VD患者的乙酰胆碱酯酶(AchE)活性降低和血浆乙酰胆(Ach)含量升高(P＜0．05)。结论:长春西汀治疗VD疗效肯定,其机制可能与胆碱能神经系统功能增强有关。
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| 关 键 词： | 长春西汀 血管性痴呆 胆碱能神经系统 |
| 文章编号： | 1006-351X（2007）03-0205-02 |
| 收稿时间： | 2007-02-28 |
| 修稿时间： | 2007-02-28 |
Vinpocetine in the treatment of vascular dementia |
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| HAN Kun,JIA Ning,MIN Lianqiu. Vinpocetine in the treatment of vascular dementia[J]. Journal of Brain and Nervous Diseases, 2007, 15(3): 205-206 |
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| Authors: | HAN Kun JIA Ning MIN Lianqiu |
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| Affiliation: | Department of neurology Liaoning medical college. Jinzhou 121001 |
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| Abstract: | Objective:To explore the effect and therapeutic mechanism of Vinpocetine in treating vascular dementia. Methods:The score of MMSE,HDS and the activity of cholinergic system in 96 patients with VD were etected and com- pared with control group in 10 and 21 days respectively.Results:The scores of MMSE and HDS of vinpocetine group were significantly higher than those of common group.Vinpocetine could decrease the activity of cholinesterase and im- prove content of acetylcholine in plasm in 21 days.Conclusions:Vinpocetine has definite effect on VD,which may im- prove the function of cholinergic system. |
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| Keywords: | Vinpocetine Vascular dementia Cholinergic nerve system |
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