| 高效液相色谱法测定富马酸氯马斯汀片的溶出度 |
| |
| 引用本文： | 王金龙,姜建国. 高效液相色谱法测定富马酸氯马斯汀片的溶出度[J]. 中国药业, 2007, 16(23): 8-9 |
| |
| 作者姓名： | 王金龙 姜建国 |
| |
| 作者单位： | 河北省药品检验所,河北,石家庄,050011 |
| |
| 摘 要： | 目的建立高效液相色谱法测定富马酸氯马斯汀片的溶出度。方法以0．1mol／L盐酸为溶出介质，转速为75r／min，色谱柱为C18柱（150mm×4，6mm，5μm），流动相为甲醇-0．01mol／mL磷酸二氢钾-三乙胺（70：29：1，用磷酸调节pH值为5．0），检测波长为220nm。结果富马酸氯马斯汀片的质量浓度在1，315～0，1578μg／mL范围内与峰面积线性关系良好，r=0．9994，平均回收率为99．29％。RSD为0，51％（n=6）。结论该法简便、准确，重现性好，能有效控制富马酸氯马斯汀片的溶出度。
|
| 关 键 词： | 富马酸氯马斯汀片 溶出度 高效液相色谱法 |
| 文章编号： | 1006-4931(2007)23-0008-02 |
| 修稿时间： | 2007-05-23 |
Determination of Dissolution of Clemastine Fumarate Tablet by HPLC |
| |
| Wang Jinlong,Jiang Jianguo. Determination of Dissolution of Clemastine Fumarate Tablet by HPLC[J]. China Pharmaceuticals, 2007, 16(23): 8-9 |
| |
| Authors: | Wang Jinlong Jiang Jianguo |
| |
| Affiliation: | Wang Jinlong, Jiang Jianguo ( Hebei Provincial Institute for Drug Control, Shijiazhuang, Hebei, China 050011) |
| |
| Abstract: | Objective To establish a method of dissolution of clemastine fumarate tablet by HPLC method. Methods 0. 1 mol/L HCI was used as dissolution medium and the rotational speed was 75 r/min. A HPLC method was used. Using Cis column （150 mm×4.6 mm,5μm）, the mobile phase was methanol-0.01 mol/L potassium dihydrogen phosphate-triethylaminum （70：29：1, pH 5.0 adjusted by phospho- ricacid） .The detection wavelength was 220 nm. Results There was linear relationship within the range of 1. 315-0. 157 8 μg/mL, r= 0. 999 4. The average recovery rate was 99. 51%. The RSD of the method was 0. 51% （n =6）. Conclusion The method is simple,accurate and reproducible. It can be used for the quality control of dissolution of Clemastinc Fumarate Tablet. |
| |
| Keywords: | clemastine fumarate tablet dissolution HPLC |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
