丹参对大鼠胫骨骨折早期愈合过程中血清、骨痂及骨组织中钙、锌、铜的影响

本实验采用原子吸收光谱法,对大鼠胫骨闭合性骨折早期愈合过程中血清、骨痂及骨组织中钙、锌、铜含量的变化以及应用丹参治疗后的影响作了研究。发现丹参可明显增加血清和骨痂中钙、锌含量及锌/铜比值,抑制血清铜水平的升高和降低骨折断端邻近骨组织中锌的含量;且骨痂钙含量与骨痂中锌/铜比值呈明显的正相关。结果提示,丹参促进骨折愈合的作用,与其提高血清锌含量、加强骨折断端邻近骨组织中锌的动员,以及通过提高骨痂中锌含量、锌/铜比值来加速骨痂组织生长和钙化过程有关。

Effect of Radix Salviae Miltiorrhizae on Calcium,Zinc,Copper Content in Serum,Callas and Bony Tissue in Early Stage of Healing Process in Rat Closed Tibial Fracture

Changes of calcium, zinc, copper contents in serum, callus and bony tissue in the early stage of the healing process of rat closed tibial fracture, also the changes of them with radix salviae miltiorrhizae (RSM) treatment were studied. It was found that calcium, zinc contents and Zn/Cu ratio increased significantly and the rise of serum copper content was inhibited by the administration of RSM after fracture. Zn/Cu ratio in fracture callus was correlated to the calcium content in fracture callus.These findings suggested that the effect of the promotion of RSM on fracture healing was related to the increased zinc content in serum, also related to the acceleration of mobilization of zinc in fractured bone,and to the acceleration of fracture callus formation and mineralization process by the increased zinc and Zn/Cu ratio in the callus of the fracture.