| 二甲亚砜治疗实验性脑水肿 |
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| 引用本文： | 金立明,虞佩兰,姜桂华,邹商群,唐外星,张淑安,彭隆祥. 二甲亚砜治疗实验性脑水肿[J]. 中南大学学报(医学版), 1989, 0(1) |
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| 作者姓名： | 金立明 虞佩兰 姜桂华 邹商群 唐外星 张淑安 彭隆祥 |
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| 作者单位： | 湖南医科大学第一附属医院儿科(金立明，虞佩兰，姜桂华，邹商群)，湖南医科大学电镜室(唐外星，张淑安)，湖南医科大学电镜室(彭隆祥) |
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| 摘 要： | 21只家兔急性脑水肿模型分为三组,脑水肿建立后3h分别静脉注入10％二甲亚砜、20％甘露醇和5％葡萄糖(空白对照);观察颅内压,脑组织含水量、血压和血尿等变化。结果表明DMSO比甘露醇降低颅内压作用快,下降幅度亦较大,但持续时间较短。用10％DMSOlg/kg的浓度和剂量快速静脉推注,未发生血尿。电镜观察二药均有减轻脑水肿的形态学改变。因此DMSO可作为一种降低颅内压减轻脑水肿的药物。
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| 关 键 词： | 百日咳菌液 脑水肿 疾病模型 动物 颅内压 二甲亚砜 甘露醇 治疗应用 兔 |
DIMETHYL SULPHOXIDE TREATMENT IN EXPERIMENTAL BRAIN EDEMA |
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| Jin Liming Yu Peilan Jiang Guihua Zou shangqun. DIMETHYL SULPHOXIDE TREATMENT IN EXPERIMENTAL BRAIN EDEMA[J]. Journal of Central South University. Medical sciences, 1989, 0(1) |
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| Authors: | Jin Liming Yu Peilan Jiang Guihua Zou shangqun |
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| Affiliation: | Jin Liming Yu Peilan Jiang Guihua Zou shangqunDepartment of Pediatrics,The First Affiliated Hospital,Hunan medical UnirersityTan Waixing Zhang Shuan Peng LongxiangLaboratory of Electron Microscope,Hunan medical Unirersity |
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| Abstract: | Twenty one rabbits with experimental brain edema induced by intracarotid injection of pertussis vaccine were randomly divided into three groups: 10% Dimethyl sulfoxide (DMSO, 20% Mannital groups, and 5%Glucose as control.3h after giving the vaccine, experimental animals received different drug therapy, all administrated intravenously. The intracranial pressure (ICP), mean arterial pressure (MAP), and brain tissue water were montored. ICP and brain edema reduced sinificantly in both DMSO and mannital groups. The ICP decrease initiated quicker but the lasting time was shorter in DMSO group than that of mannital group.No obvious hematuria was found in DMSO group. It is suggust-ed that DMSO may be used in reducting ICP. |
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| Keywords: | pertussis vaccine brain edema disease modle animal intracranial pressure dimethyl sulfoxide mannital therapeutic use rabbit |
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