形态学酷似幼淋巴细胞白血病的急性髓系白血病

为了探讨形态学酷似幼淋巴细胞白血病（PLL）的急性髓系白血病（AML）的临床、骨髓细胞形态学、免疫表型及细胞遗传学特点，用显微镜观察骨髓细胞形态学特点，用流式细胞术检测骨髓细胞的免疫表型，用传统的细胞遗传学方法分析骨髓细胞核型，用荧光原位杂交技术测定骨髓细胞的杂交信号。结果表明：该患者的临床特点表现为急性白血病，骨髓细胞形态学提示为淋巴系统疾病，但免疫表型分析亦为髓系抗原表达，细胞遗传学分析该例患者存在8号染色体三体，对化疗反应性差。结论：急性髓系白血病细胞形态学可表现淋巴细胞样特点，结合免疫分型有助于进一步确定白血病细胞的类别分型，

Acute Myeloid Leukemia with the Morphological Characteristics of Prolymphocytic Leukemia

To investigate the clinical,cellular morphology,immunophenotype,and cytogenetic characteristics of acute myeloid leukemia(AML) which are very similar to the morphological characteristics of prolymphocytic leukemia(PLL),the morphological features of bone marrow cells from patient were observed by light microscope,the immunopherotypes were detected by flow cytometry,the karyotypes were analyzed by conventional cytogenetic method,the hybridization signals were determined by fluorescence in situ hyiridization.The results indicated that the clinical features were in accordance with acute leukemia and the immunophenotyping results showed malignant cells originated from myeloid lineage,while the cytomorphology analysis showed that the blastic cells were more like the lymphoid lineage.Trisomy 8 was found in the patient by cytogenetic study,the patient did not show good response to chemotherapy.In conclusion,acute leukemia has high heterogenicity,which could be defined as AML,but more like lymphocytic origination by morphological study.Immunophenotyping analysis could contribute to the final diagnosis of malignant cells.