Phase II trial of anaxirone (1,2,4-triglycidylurazol,TGU) in patients with advanced ovarian carcinoma: an EORTC gynecological cancer cooperative group study |
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| Affiliation: | 1. School of Pharmacy, Shanghai University of Medicine & Health Sciences, Shanghai, China;2. College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, China;3. Bio-ID Center, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China |
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| Abstract: | ![]()
Sixteen patients with advanced ovarian carcinoma were treated with anaxirone (1,2,4-trigycidyl urazol, TGU), 600 mg/m2 every 4 weeks. Anaxirone was the second or later line of therapy. All patients had evaluable tumors and evidence of failure of prior therapy. None of the patients responded. Two had stabilization of the disease for 4 months. In one patient WHO grade 4 leukopenia and grade 4 thrombocytopenia were observed after the second TGU cycle starting on day 41 and persisted until the patient died due to tumor progression (day 50). No patient experienced thrombophlebitis. |
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