内皮素-1基因5'非翻译区多态性与体位性低血压相关性研究

目的探讨内皮素-1基因5’非翻译区一个功能性多态+138A/-与体位性低血压的关系。方法运用聚合酶链反应和限制性内切酶片段长度多态性方法分析381例未治疗高血压患者和291例血压正常者的内皮素-1基因+138A/-基因多态性。所有入选者均进行卧立位血压测量。结果高血压人群中体位性低血压患者与非体位性低血压组比较,内皮素-1基因+138A/-基因型和A等位基因频率差异无显著意义(14.7%vs.15.3%,P0.05)。正常血压人群中得到相似的结果(13.9%vs.15.7%,P0.05)。校正年龄、体重指数、卧位血压等因素后,高血压人群和正常人群中+138A/-各基因型间收缩压和舒张压体位性变化均无显著差异。结论在高血压人群和正常血压人群中均未发现内皮素-1基因+138A/-多态性与体位性低血压存在相关性的证据。

The Association of an Insertion Variant in the 5'UTR of the Endothelin-1 Gene with Orthostatic Hypotension in Hypertensive and Normotensive Subjects

Objective To assess the association of a functional adenine insertion polymorphism in the 5＇ untranslated region of endothelin-1 gene with orthostatic hypotension in hypertensive and normotensive subjects.Methods The adenine insertion polymorphism was genotyped in 381 untreated hypertensive patients and 298 normotensive subjects,who all underwent an upright posture study for orthostatic blood pressure measurements.Results No signif icant differences in the genotype/allele frequencies of the adenine insertion polymorphism were found between patients with and without orthostatic hypotension in both hypertensive（14.7% vs.15.3%,P0.05）） and normotensive subjects（13.9% vs.15.7%,P0.05）.Also no signif icant associations were found between the insertion polymorphism and orthostatic systolic and diastolic blood pressure changes even after adjustment for age,sex,body mass index and supine systolic and diastolic blood pressure.Conclusion These data provide no evidence for the association between the functional adenine insertion polymorphism in the 5＇ UTR of endothelin-1 gene and orthostatic hypotension risk in both hypertensive patients and normotensive subjects.