| p53蛋白和增殖细胞核抗原在妊娠滋养细胞疾病中的表达 |
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| 引用本文： | 方光光,黄铁军,刘志恒. p53蛋白和增殖细胞核抗原在妊娠滋养细胞疾病中的表达[J]. 华中医学杂志, 2003, 27(3): 131-132 |
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| 作者姓名： | 方光光 黄铁军 刘志恒 |
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| 作者单位： | 518035,深圳,深圳市第二人民医院;430030,武汉,华中科技大学同济医学院附属同济医院 |
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| 摘 要： | 目的：观察p53蛋白、增殖细胞核抗原(PCNA)与妊娠滋养细胞疾病(GTD)及其良恶性之间的关系。方法：对48例GTD和24例正常妊娠绒毛组织的石蜡标本进行p53蛋白和PCNA免疫组化染色,比较各类疾病中二者的阳性率。结果：p53蛋白与PCNA在正常绒毛、良性葡萄胎、恶性滋养细胞疾病3组中表达均有权显著性差异(P＜0．01)。结论：p53蛋白和PCNA在GTD的生物行为中有着相似的意义。
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| 关 键 词： | p53蛋白 增殖细胞核抗原 妊娠滋养细胞疾病 |
| 修稿时间： | 2003-03-10 |
Expression of p53 Protein and Proliferating Cell Nuclear Antigen in Human Gestational Trophoblastic Diseases |
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| Fang Guangguang,Huang Tiejun,Liu Zhiheng. Shenzhen Second People's Hospital,Shenzhen. Expression of p53 Protein and Proliferating Cell Nuclear Antigen in Human Gestational Trophoblastic Diseases[J]. Central China Medical Journal, 2003, 27(3): 131-132 |
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| Authors: | Fang Guangguang Huang Tiejun Liu Zhiheng. Shenzhen Second People's Hospital Shenzhen |
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| Affiliation: | Fang Guangguang~1,Huang Tiejun~1,Liu Zhiheng. ~1 Shenzhen Second People's Hospital,Shenzhen 518035 |
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| Abstract: | Objective To study the relationship between p53 protein, proliferating cell nuclear antigen (PCNA) and benign or malignant gestational trophoblastic disease (MGTD). Methods The histological sections of 48 cases of gestational trophoblastic disease and 24 eases of normal chorionic villi were stained using immunohistochemistry, and the monoclonal, antibodies were used to determine p53 protein and PCNA. Results The frequency of positive p.53 and positive PCNA were significantly different among the chorionic villi of normal pregnancy, hydratidiform mode (HM) and MGTD. But neither p53 nor PCNA had any relation with the clinical staging or metastasis of MGTD. Conclusion Both p53 and PCNA are valuable in diagnosis of human gestational trophoblastic disease. |
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| Keywords: | P53 protein Proliferating cell nuclear antigen Gestational trophoblastic diseases |
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