| 急性早幼粒细胞白血病中白血病细胞CD117的表达 |
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| 引用本文： | 万岁桂,徐娟,巩文玉,孙雪静,田丁. 急性早幼粒细胞白血病中白血病细胞CD117的表达[J]. 首都医科大学学报, 2004, 25(2): 227-229 |
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| 作者姓名： | 万岁桂 徐娟 巩文玉 孙雪静 田丁 |
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| 作者单位： | 首都医科大学宣武医院血液科;北京儿童医院血液中心 |
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| 摘 要： | 为观察CD117分子在急性早幼粒细胞白血病 (APL)中的表达及探讨其意义 ,采用三色流式细胞术对 2 2例APL骨髓白血病细胞表面CD117的表达进行分析。结果 :CD117在APL中的表达率为 1 9/2 2 ,在急性粒细胞白血病(AML M1)和AML M2 中的表达率分别为 2 /2和 1 8/2 1。 1 9例CD117+ 的APL患者中 ,1 8例CD34 - 、HLA DR- ,1例部分细胞HLA DR+ 。提示 :APL患者有较高水平的CD117表达 ,CD117与CD34 、HLA DR联合进行多色流式细胞术分析 ,可用于APL微小残留病灶的检测。
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| 关 键 词： | 急性早幼粒细胞白血病 CD117 免疫分型 微小残留病灶 |
| 收稿时间： | 2003-04-06 |
| 修稿时间： | 2003-04-06 |
Expression of CD117 in Acute Promyelocytic Leukemia |
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| Wan Suigui,Xu Juan,Gong Wenyu,Su Xuejing,Tian Ding. Expression of CD117 in Acute Promyelocytic Leukemia[J]. Journal of Capital Medical University, 2004, 25(2): 227-229 |
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| Authors: | Wan Suigui Xu Juan Gong Wenyu Su Xuejing Tian Ding |
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| Affiliation: | 1. Department of Hematology, Xuanwu Hospital, Affiliate of Capital University of Medical Sciences;2. Department of Hematology, Beijing Children Hospital |
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| Abstract: | The aim was to investigate the expression of CD 117 in acute promyelocytic leukemia and its significance. The expression of CD 117 was detected using three-color flow cytometry. CD 117 was positive in 19/22 of patients with acute promyelocytic leukemia(APL), in 2/2 and 18/21 of patients with AML-M 1 and AML-M 2 respectively. Among nineteen APL patients with CD 117 , eighteen were CD 34 - and HLA-DR -. Only one patient was partial HLA-DR . There was high level expression of CD 117 in acute promyelocytic leukemia. Minimal residual disease of APL can be detected using multi-color flow cytometry to analyze the expression of CD 117 , CD 34 and HLA-DR. |
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| Keywords: | acute promyelocytic leukemia CD 117 immunophenotype minimal residual disease |
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