老年高血压患者血压变异性与动脉粥样硬化的相关性研究

目的研究老年高血压患者血压变异性与动脉硬化之间的关系。方法 126例老年高血压患者,按有无合并冠状动脉粥样硬化性心脏病分为两组。测定臂踝脉搏波传导速度,并采用无创血压监测仪行24h血压监测,分析高血压患者24h、白天及夜间收缩压和舒张压变异性。结果 EH+CHD组臂踝脉搏波传导速度高于EH岁组(P<0.05);EH+CHD组日间收缩压标准差(dSBP-SD)、24h收缩压标准差(24hSBP-SD)均显著高于EH组(P<0.01或0.05);24hSBP-SD、DSBP-SD与PWV呈显著正相关。结论血压变异性与动脉粥样硬化、动脉扩张性有着密切的关系,控制血压、降低血压变异性对延缓动脉粥样硬化进展起到了重要作用。

Study on the Relationship between Blood Pressure Variability and Atherosclerosis in Elderly Patients with Essential Hypertension

Objective To investigate the relationship between blood pressure variability and the arterial distensibility in elderly patients with essential hypertension. Methods A total of 126 elderly hypertensive patients were divided into two groups. Auto-survey atherosclerosis apparatus was applied to examine brachial-ankle pulse wave velocity （baPWV）. Ambulatory blood pressure monitoring was examined to calculate the systolic and diastolic BP variability. Results BaPWV were significantly higher in EH＋CHD group than in EH group （P〈0.05）. DSBP-SD and 24bSBP-SD in EH patients with CHD group were significantly higher than those in EH patients without CHD group （P〈0.05 or P〈0.01）. Pearson correlation analysis showed that 24 hSBP-SD, DSBP-SD were significantly related to PWV. Conclusion There was positive association between blood pressure variability and arterial distensibility in hypertension patients.