Sox4和E-cadherin在子宫颈鳞状细胞癌中的表达及临床意义

目的:研究转录因子Sox4和上皮间质转化相关蛋白上皮型钙黏蛋白（E-cadherin）在子宫颈鳞状细胞癌（CSCC）中的表达及相关性，为临床的诊断和治疗提供依据。方法:将160例CSCC定义为观察组，28例癌旁组织定义为对照组，利用免疫组织化学S-P法，检验2组Sox4和E-cadherin蛋白表达及其与临床病理参数之间的关系。结果:Sox4在观察组阳性率为63.75%，高于对照组的39.29%（P<0.05），E-cadherin观察组阳性率为35.00%，低于对照组的64.29%（P<0.01）；Sox4与E-cadherin阳性表达呈负相关关系（r_s=-0.54，P<0.01）；且与肿瘤直径、病理分级、淋巴结转移、宫旁浸润和FIGO分期密切相关（P<0.05~P<0.01），与病人年龄未见相关性（P>0.05）。结论:Sox4可能通过下调E-cadherin促进CSCC发生、发展、侵袭和转移，联合检测二者可为CSCC的早期诊断、治疗和预后提供参考。

Expressions of Sox4 and E-cadherin in cervical squamous cell carcinoma and their clinical significance

Objective:To investigate the expression levels of SRY-related HMG-box 4(Sox4)and epithelial-mesenchymal transition related protein E-cadherin in cervical squamous cell carcinoma(CSCC),and their clinical significance.Methods:The expression levels of Sox4 and E-cadherin proteins in CSCC group(160 cases)and control group(28 cases)were detected by S-P immunohistochemical method,and the relationships between which and clinicopathological parameters were analyzed.Results:The positive rate of Sox4 in observation group(63.75％)was higher than that in control group(39.29％)(P <0.05).The positive rate of E-cadherin in observation group(35％)was lower than that in control group(64.29％)(P<0.05).The expression level of Sox4 was negatively correlated with E-cadherin(P<0.01),closely related to the tumor diameter,lymph node metastasis,parametrial infiltration and FIGO stage(P<0.05 to P <0.01),and unrelated to the age of patients(P >0.05).Conclusions:Sox4 may promote the occurrence,development,invasion and metastasis of CSCC by down-regulating the E-cadherin protein.The combined detection of Sox4 and E-cadherin can provide the reference in early diagnosis,treatment and predicting the prognosis of patients with CSCC.