| 生长因子和细胞外基质与脊髓损伤 |
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| 引用本文： | 贾小力,陈少强. 生长因子和细胞外基质与脊髓损伤[J]. 医学综述, 2007, 13(18): 1368-1370 |
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| 作者姓名： | 贾小力 陈少强 |
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| 作者单位： | 福建医科大学解剖学与组胚学系,福州,350004 |
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| 基金项目： | 教育部科学技术研究重点项目;福建省科技厅科技计划;福建省福州市科技局科研项目 |
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| 摘 要： | 脊髓损伤(SCI)是神经科学领域内一道尚未解决的难题。多项研究表明生长因子和细胞外基质是构成中枢神经系统微环境的必不可少的成分,研究它们在SCI和修复中所起的作用,有利于找到针对性的治疗手段,从而最大程度地提高SCI后的功能恢复。本文对神经生长因子、脑源性神经营养因子、神经营养因子3、血管内皮生长因子、转化生长因子β1、细胞因子和促进或抑制轴突再生的细胞外基质蛋白在SCI中的作用作一综述。
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| 关 键 词： | 生长因子 细胞外基质 脊髓损伤 |
| 文章编号： | 1006-2084（2007）18-1368-03 |
| 收稿时间： | 2006-12-16 |
| 修稿时间： | 2007-07-23 |
Growth Factor as well as Extracellular Matrix and Spinal Cord Injury |
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| JIA Xiao-li,CHEN Shao-qiang. Growth Factor as well as Extracellular Matrix and Spinal Cord Injury[J]. Medical Recapitulate, 2007, 13(18): 1368-1370 |
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| Authors: | JIA Xiao-li CHEN Shao-qiang |
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| Affiliation: | Department of Anatomy and Histology-Embryology;Fujian Medical University;Fuzhou 350004;China |
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| Abstract: | Spinal cord injury(SCI) is the unsettled hot nut in neuroscience.Multiple researches showed that growth factors and extracellular matrix are indispensable component in constructing microenvironment of central nervous system,of which the study about their role played in SCI and repairment is helpful to seek specific therapeutic methods and to promote functional recovery after SCI in the maximum.This article reviews effects of nerve growth factor(NGF),brain-derived neurotrophic factor(BDNF),neurotrophic factor-3(NT-3),vascular endothelial growth factor(VEGF),transforming growth factor-β1(TGF-β1),cytokine(CK)and ECM promoting or inhibiting regeneration of injured axons on SCI. |
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| Keywords: | Growth factor Extracellular matrix Spinal cord injury |
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