肿瘤相关巨噬细胞的极化与肿瘤的发展

肿瘤相关巨噬细胞（TAM）在肿瘤微环境中扮演重要角色，它包含了两种可以相互极化的亚型:M1型(经典活化巨噬细胞)和M2型（替代活化巨噬细胞）。M1型TAM发挥着抑制肿瘤生长的作用，而M2型TAM对肿瘤的发生发展起促进支持作用。在特定的肿瘤微环境中，M2型TAM占据主导地位，促进肿瘤的发展。基于肿瘤相关巨噬细胞两种亚型的功能特点，如何诱导M2型向M1型极化是目前的研究热点，也将是肿瘤治疗的一个重要靶点。

The polarization of tumor associated macrophages and tumor progression

Tumor associated macrophages (TAM) play important role in the tumor microenvironment.It contains two phenotypes:M1 macrophages(classically activated macrophages) and M2 macrophages(alternatively activated macrophages).M1 macrophages inhibit tumor growth,while M2 macrophages promote tumor progression.In specific tumor microenvironment,M2 macrophages occupy a dominant position,and influence cancer progression and metastasis.Macrophages respond differently to various microenvironmental signals and display distinct functions.Thus,driving TAM activation toward a more dominant anti-cancer M1 phenotype might be a potential therapeutic strategy.