| 半边旗中二萜类化合物5F对K562细胞几种癌基因表达的影响 |
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| 引用本文： | 王京滨,梁念慈,莫丽儿. 半边旗中二萜类化合物5F对K562细胞几种癌基因表达的影响[J]. 中国药理学通报, 2002, 18(4): 418-421 |
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| 作者姓名： | 王京滨 梁念慈 莫丽儿 |
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| 作者单位： | 1. 广东医学院生物化学与分子生物学研究所
2. 广东医学院化学教研室,湛江,524023 |
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| 基金项目： | 广东省科委重大科技攻关项目 (No 962 2 0 0 7 0 0 2 )，国家自然科学基金资助课题 (No 3 9870 90 0 ) |
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| 摘 要： | 目的 研究半边旗中二萜类化合物 5F(11α 羟基 15 氧 16 烯 ent贝壳杉烷 19酸 )对K5 6 2细胞癌基因Bcl 2、Bax、c Fos、c Jun表达的影响。方法 5F作用K5 6 2细胞 2 4h后 ,用蛋白印迹法检测Bcl 2、Bax、c Fos、c Jun的表达。结果 半边旗中二萜类化合物 5F作用于K5 6 2细胞 2 4h后 ,Bcl 2表达减少 ,Bax、c Fos、c Jun表达增多。结论 推测化合物 5F抗肿瘤的机制之一是上调Bax、c Fos、c Jun表达和下调Bcl 2的表达
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| 关 键 词： | 半边旗 二萜类 癌基因 |
| 文章编号： | 1001-1978(2002)04-0418-04 |
| 修稿时间： | 2001-12-20 |
The effects of a diterpenoid compound 5F isolated from Pteris semipinnata L. on the expressions of several oncogenes of K562 cells |
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| WANG Jing Bin,LIANG Nian Ci,MO Li Er. The effects of a diterpenoid compound 5F isolated from Pteris semipinnata L. on the expressions of several oncogenes of K562 cells[J]. Chinese Pharmacological Bulletin, 2002, 18(4): 418-421 |
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| Authors: | WANG Jing Bin LIANG Nian Ci MO Li Er |
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| Affiliation: | WANG Jing Bin,LIANG Nian Ci,MO Li Er 1 |
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| Abstract: | AIM To study the effects of diterpenoid compound 5F (ent 11α hydroxy 15 oxo kaur 16 en 19 oic acid) isolated from Pteris Semipinnata L. on the expressions of Bcl 2?Bax?c Fos and c Jun of K562 cells. METHODS K562 cells were treated with compound 5F for 24 hours first. Then Western blotting was used to detect the effects of compound 5F on the expressions of Bcl 2?Bax?c Fos and c Jun. RESULTS The expression of Bcl 2 decreased while the expression of Bax, c Fos and c Jun increased after the treatment of 5F. CONCLUSIONS One possible mechanism of the anti tumor effects of compound 5F may be through up Bax, c Fos, c Jun and down Bcl 2 regulation. |
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| Keywords: | Pteris semipinnata L. diterpenoid oncogene |
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