缬沙坦对原发性高血压患者血管内皮功能及臂踝脉搏波传导速度的影响

目的 探讨缬沙坦对原发性高血压患者血管内皮功能及臂踝脉搏波传导速度(baPWV)的影响.方法 检测30例原发性高血压患者应用缬沙坦治疗前后血压、血一氧化氮(NO)及臂踝脉搏波传导速度的变化.结果 应用缬沙坦后,原发性高血压患者血压及臂踝脉搏波传导速度显著下降(P<0.05及P<0.01)、N0明显提高(P<0.01),且臂踝脉搏波传导速度下降与NO升高之间具有相关性(r=-0.71,P<0.01).结论 缬沙坦除可有效降压外,还有逆转原发性高血压患者血管内皮功能、改善大动脉弹性的作用,同时臂踝脉搏波传导速度可用于评估缬沙坦时血管内皮功能的改善程度.

Effect of valsartan on vascular endothelial function and brachial-ankle pulse wave velocity in patients with essential hypertension

Objective To investigate the effect of valsartan on vascular endothelial function and brachial-ankle pulse wave velocity(baPWV)in patients with essential hypertension(EH).Methods Blood pressure,NO value and brachial-ankle pulse wave velocity were determined and analyzed in 30 patients with essential hypertension before and after therapy of valsartan.Results Both blood pressure and brachial-ankle pulse wave velocity wefe re-duced greafly(P<0.05 and P<0.01),while serum NO increased significantly(P<0.01)following valsartan thera-Py,and brachial-ankle pulse wave velocity was well correlated to serum NO(r=-0.71,P<0.01).Conclusions Valsartan is not onlv effective in the control of blood pressure,but also effective in reveming the impaired endothelial function and artery elasticity in patients with essential hypertension,at the same time brachial-ankle pulse wave ve-locity is also good surrogate of endlothelial functional improvement induced by Valsartan therapy.