S100蛋白检测在脑梗死中的应用研究

目的：探讨S100蛋白检测在脑梗死（CI）中的作用价值。方法分析我院自2012年1月~2013年4月收治的76例CI患者，检测S100蛋白在CI患者发病后第3、7、14天时的水平，以及与神经功能缺损评分、脑梗死病灶面积大小的关系。同时选取我院同期行健康体检患者56例进行对照分析。结果（1）CI组与对照组比较，在术后3d与7d时，S100蛋白水平比较，P＜0.01，P＜0.05。（2）神经功能缺损评分中型、重型组与轻型组S100蛋白水平比较，P＜0.05，P＜0.01。（3）梗死面积中、大组与小梗死面积组比较，P＜0.05， P＜0.01。结论 S100蛋白在CI发病早期为高表达，同时其高表达神经功能缺损严重程度及梗死面积增大有密切关系，表明S100蛋白与CI的病理、生理的过程有一定的相关性。

Study of application of S100 protein detection in cerebral infarction

Objective To investigate the application value of S100 protein detection in cerebral infarction （CI）. Methods Seventy-six CI patients admitted to our hospital from January 2012 to April 2013 were analyzed. The patients＆#39;S100 protein levels on day 3,7 and 14 were detected and their correlation to neurological deficits and cerebral infarction lesion size was studied. Meanwhile,56 healthy people receiving physical examination in the corresponding period received contrast analysis. Results （1）S100 protein levels were significantly different between the CI group and the control group on postoperative day 3 and day 7,P〈0.01, P〈0.05.（2）S100 protein levels were significantly different between middle,severe and mild neurological deficits,P 〈 0.05,P 〈 0.01.（3）The middle,large and small-sized infarction groups were significantly different （P 〈 0.05,P 〈 0.01）. Conclusion S100 protein is highly expressed in the early stage of CI onset and meanwhile its high expression is closely related to the degree of neurological deficits and the size of infarction, which indicates that S100 protein has certain correlation to the pathological and physiological process of CI.