下肢慢性静脉性溃疡病因学的研究进展

下肢慢性静脉溃疡（CVLU）是下肢慢性静脉功能不全（CVI）最严重和难治的并发症，以下肢静脉系统持续高压为特征，其临床主要表现为皮肤破溃、下肢疼痛，常伴随有下肢静脉曲张及皮肤色素沉着等症状，多好发于小腿中下段前内侧、外踝以及足背，常为单发，也可为多发，久治不愈或是反复发作，给患者的生活及工作造成极大的影响，甚至使其丧失劳动能力，严重地影响了患者的健康，降低了患者的生活质量。高发病率、难治性及高复发率使CVLU成为临床工作中较为棘手的问题，其致病危险因素较多且复杂，病因及发病机制尚未完全统一，迄今已有多种不同的解释和理论，本文就近年来CVLU病因学的研究进展作一综述。

The progress in the etiology of chronic venous leg ulcers

Chronic venous leg ulcer（CVLU） is the most severe and intractable complications of chronic lower limb venous insufficiency（CVI）,persistent hypertension of the venous system is the characteristic of CVLU,the main clinical manifestations are ulceration and ache of lower limbs,and always accompanied by varicose veins of lower extremity and pigmentation and so on.h often occurs in the medial of lower legs, lateral malleolus and dorsum pedis. Single or multiple,after a long time will not heal or recurrent.The disease causes great influence on the work and life of patients,even make the patients disabled.The disease can cause great influence to the health of patients, and will reduce the patient＇s quality of life.h becomes a thorny problem in clinical practice because of its high incidence, refractory and high recurrence rate. The causes of various interpretations and theory, has not been comp!etely unified, people have proposed many different interpretations and theory,this article reviews the progress in the etiology of CVLU in recent years.