二甲双胍治疗青春期多囊卵巢综合征患者的效果分析

目的探讨二甲双胍治疗青春期多囊卵巢综合征患者的临床疗效。方法回顾性分析我院2011～2013年妇科收治的80例青春期多囊卵巢综合征患者的资料，随机分为观察组及对照组，各40例，两组均采用达英-35治疗，观察组患者加用二甲双胍片，连续治疗3个月，比较两组患者治疗前后血浆性激素、空腹血糖及空腹胰岛素变化情况。结果两组患者血浆性激素FSH、LH、LH／FSH、T指标均下降，观察组患者下降更为明显，比较差异有统计学意义（P〈0．05）；两组患者FBS、FIN及HOMA—IR均有改善，观察组患者改善更明显，比较差异有统计学意义（P〈0．05）。结论二甲双胍联合达英-35治疗青春期多囊卵巢综合征，能改善患者临床症状、卵巢功能及胰岛素抵抗，有效降低雄激素水平，疗效满意。

Effect analysis of metformin treatment of adolescent polycystic ovary syndrome

Objective To investigate the clinical efficacy of metformin therapy for patients with adolescent polycystic ovary syndrome. Methods Eighty patients with adolescent polycystic ovary syndrome admitted to our hospital from 2011 to 2013 were analyzed retrospectively and randomly divided into the observation group and the control group, with 40 patients in each group. Both groups received Diane-35 treatment and the observation group received additional metformin tablets. After 3 months of continUous treatment, the plasma sex hormone, fasting glucose and fasting insulin changes of the two groups were compared. Results Both groups of patients had decreased plasma sex hormone FSH, LH, LH/FSH and T indicators, and the observation group decreased more obviously, with statistically significant differences（P 〈 0.05）; Both groups of patients had improved FBS, FIN and HOMA-IR, and the observation group improved more obviously, with statistically significant differences（P 〈 0.05）. Conclusion In the treatment of adolescent polycystic ovary.syndrome, Diane-35 combined with metformin can improve the patients＇ clinical symptoms, ovarian function and insulin resistance and effectively reduce androgen levels, showing satisfactory results.